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Top 25 VCs for Deep Tech Startups in North America in 2025

Top 25 VCs for Deep Tech Startups in North America in 2025

Deep tech startups are revolutionizing multiple industries, and the landscape is brimming with innovative ventures. To fuel these cutting-edge advancements, venture capital firms play a crucial role. Here, we list the top 25 venture capital (VC) firms to watch for deep tech startups in North America in 2025.
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1. Sequoia Capital

Investment Focus: AI, robotics, healthcare, and energy Location: Menlo Park, CA Notable Investments: OpenAI, Stripe, LinkedIn Learn more about Sequoia Capital

2. Andreessen Horowitz

Investment Focus: Biotech, AI, crypto, and consumer tech Location: Menlo Park, CA Notable Investments: Coinbase, Airbnb, Oculus VR Explore Andreessen Horowitz

3. Lux Capital

Investment Focus: Biotech, AI, and advanced manufacturing Location: New York, NY Notable Investments: Anduril, Zoox, Shapeways Discover Lux Capital
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4. Kleiner Perkins

Investment Focus: Biotech, cybersecurity, and green tech Location: Menlo Park, CA Notable Investments: Google, Amazon, Genentech Visit Kleiner Perkins

5. Data Collective (DCVC)

Investment Focus: Machine learning, quantum computing, and space technology Location: Palo Alto, CA Notable Investments: Planet Labs, Zymergen, Rocket Lab Learn more about DCVC

6. SOSV

Investment Focus: Health tech, climate tech, and food tech Location: Princeton, NJ Notable Investments: NotCo, Opentrons, Formlabs Explore SOSV

7. Union Square Ventures

Investment Focus: Crypto, AI, and SaaS Location: New York, NY Notable Investments: Twitter, Coinbase, Duolingo Discover Union Square Ventures

8. Accel

Investment Focus: AI, cybersecurity, and cloud software Location: Palo Alto, CA Notable Investments: Facebook, Dropbox, Slack Visit Accel

9. Founders Fund

Investment Focus: Space tech, AI, and defense Location: San Francisco, CA Notable Investments: SpaceX, Palantir, Stripe Learn more about Founders Fund

10. 83North

Investment Focus: Deep tech, cloud, and machine learning Location: London, UK / Herzliya, Israel Notable Investments: Just Eat, Wolt, Mirakl
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11. Bessemer Venture Partners

Investment Focus: AI, biotech, and fintech Location: Menlo Park, CA Notable Investments: LinkedIn, Twilio, Yelp Explore Bessemer Venture Partners

12. Khosla Ventures

Investment Focus: Health tech, big data, and sustainable energy Location: Menlo Park, CA Notable Investments: Guardant Health, QuantumScape, DoorDash Discover Khosla Ventures

13. Lightspeed Venture Partners

Investment Focus: Enterprise tech, consumer tech, and deep tech Location: Menlo Park, CA Notable Investments: Snapchat, Affirm, MuleSoft Visit Lightspeed Venture Partners

14. General Catalyst

Investment Focus: Digital health, AI, and marketplace Location: Cambridge, MA Notable Investments: Airbnb, Stripe, Gusto Learn more about General Catalyst

15. SV Angel

Investment Focus: AI, biotech, and consumer tech Location: San Francisco, CA Notable Investments: Airbnb, Twitter, Dropbox Explore SV Angel
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16. Benchmark

Investment Focus: SaaS, marketplaces, and social media Location: San Francisco, CA Notable Investments: Uber, eBay, Snapchat Discover Benchmark

17. GV (formerly Google Ventures)

Investment Focus: AI, life sciences, and robotics Location: Mountain View, CA Notable Investments: Uber, Slack, Nest Visit GV

18. Alumni Ventures Deep Tech Fund

Investment Focus: AI, quantum computing, and space Location: Manchester, NH Notable Investments: Modern Meadow, SpinLaunch, AQ BioPharma Learn more about Alumni Ventures

19. Pear VC

Investment Focus: SaaS, deep tech, and consumer Location: Palo Alto, CA Notable Investments: Guardant Health, DoorDash, JetInsight Explore Pear VC

20. GGV Capital

Investment Focus: AI, big data, and robotics Location: Menlo Park, CA Notable Investments: Square, Slack, Grab Discover GGV Capital

21. Index Ventures

Investment Focus: AI, robotics, and genomics Location: San Francisco, CA Notable Investments: Deliveroo, Robinhood, Adyen Visit Index Ventures

22. First Round Capital

Investment Focus: Consumer, enterprise, and health tech Location: San Francisco, CA Notable Investments: Square, Uber, Roblox Learn more about First Round Capital

23. Trinity Ventures

Investment Focus: SaaS, digital health, and deep tech Location: Menlo Park, CA Notable Investments: Starbucks, New Relic, MuleSoft Explore Trinity Ventures

24. OpenAI Startup Fund

Investment Focus: AI, machine learning, and robotics Location: San Francisco, CA Discover OpenAI Startup Fund

25. DeepTech Ventures

Investment Focus: Quantum computing, AI, and advanced materials Location: Palo Alto, CA Visit DeepTech Ventures
These VCs are at the forefront of the deep tech revolution, and their investments are shaping the future across multiple industries. Stay connected with them to explore opportunities and drive innovation in 2025 and beyond.
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FAQ

Q: Which VC firm tops the rankings for deeptech startups in North America for 2025?
A: SOSV is frequently mentioned as a leading investor in deeptech startups. Discover more about SOSV.
Q: What firms are known for a strong focus on health tech and AI within deeptech?
A: Lux Capital and DCVC have a significant focus on health tech and AI. Read more about Lux Capital.
Q: Can you name a few VC firms that invest in quantum computing startups?
A: Cottonwood Technology Fund and Wavemaker Partners are active in the quantum computing space. Learn more about these firms.
Q: Which VCs are prominent in the robotics sector in North America?
A: Accel and Sequoia Capital are significant contributors in the robotics sector. Learn more about Accel.
Q: What are some VCs with major investments in climate tech?
A: 83North and Trinity Ventures have strong investment in climate tech startups. Explore more about Trinity Ventures.
Q: What sources mention VCs focused on semiconductors?
A: General Catalyst and Lightspeed Venture Partners are highlighted for their investments in semiconductors. Discover more about General Catalyst.
Q: Are there any VCs significantly investing in autonomous mobility?
A: ICONIQ Capital and Index Ventures have shown notable investments in autonomous mobility. Find out more about ICONIQ Capital.
Q: Which VC firms are recognized for funding deeptech startups working on gene editing?
A: Elaia Partners and Aglaé Ventures are known for supporting gene editing startups. Explore more about Elaia Partners.
Q: Which VCs are involved in investing in deeptech startups within the defense sector?
A: OTB Ventures and Verve Ventures are active investors in the defense sector. Read more about Verve Ventures.
Q: Are there any particular VCs noted for their high number of unicorns in their portfolio?
A: Union Square Ventures and Kleiner Perkins have portfolios with numerous unicorns. Discover more about Union Square Ventures.

About the Author

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
2025-06-07 08:27 Top 25