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Top 15 Incubators for AI Startups in South America in 2025: A Comprehensive Overview

Top 15 Incubators for AI Startups in South America in 2025: A Comprehensive Overview

As the AI startup ecosystem in South America continues to mature, various incubators and accelerators are emerging to help entrepreneurs navigate this rapidly evolving landscape. The following are the Top 15 Incubators for AI Startups in South America for 2025, detailing their locations, key benefits, and what makes them stand out in this competitive environment.
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1. Start-Up Chile

Location: Santiago, Chile
Description: Start-Up Chile is one of the largest startup incubators in Latin America, recognized for its extensive reach and commitment to fostering innovation.
Key Benefits:
  • Startups Accelerated: 1,960 startups accelerated to date.
  • Valuation: Combined valuation of $2.1 billion among accelerated startups.
  • Programs Offered: Pre-acceleration and acceleration programs with funding options.
  • Funding: Offers $12,000 in pre-acceleration and $30,000 in acceleration funding.
  • Explore Start-Up Chile
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2. Google for Startups Accelerator Brazil

Location: SĂŁo Paulo, Brazil
Description: This Google-backed accelerator program is designed to provide resources and mentorship specifically tailored for Brazilian startups.
Key Benefits:
  • Focus: Emphasis on technology startups with an AI component.
  • Investment: Funding ranges from $500,000 to $2 million for eligible organizations.
  • Network: Offers access to Google’s vast global network and expertise.
  • Learn more about Google for Startups Accelerator
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3. Wayra

Location: Various locations in Brazil, Peru, Venezuela, and more
Description: Wayra, the startup accelerator of TelefĂłnica, targets tech startups across multiple countries.
Key Benefits:
  • Industry Support: Wide-ranging focus on technology startups.
  • Connections: Helps connect startups to TelefĂłnica’s extensive customer base.
  • Funding: Provides funding opportunities and valuable mentorship.
  • Discover Wayra

4. 500 Startups LatAm

Location: Mexico City, Mexico
Description: A prominent early-stage investment fund with a focus on startups across Latin America.
Key Benefits:
  • Investment: Provides $60,000 to eligible startups.
  • Programs: Conducts two annual programs supporting ten startups each.
  • Networking: Access to a network of mentors and business connections.
  • Check out 500 Startups LatAm

5. Mass Challenge

Location: Mexico
Description: A leading startup accelerator focused on high-impact startups with a “Zero cost and for zero equity” model.
Key Benefits:
  • Startups Accelerated: 167 since inception in 2016.
  • Funding Raised: Total funding raised by startups at $132 million.
  • Selectivity: Maintains high selectivity with only 5% acceptance rate.
  • Explore Mass Challenge

6. NXTP Labs

Location: Argentina, Chile, Colombia, Mexico, and Uruguay
Description: An accelerator program focused on innovative technology startups across several countries in the region.
Key Benefits:
  • Focus Area: Targets startups emphasizing disruptive technologies, including AI.
  • Network Access: Provides connections to experienced entrepreneurs and mentors.
  • Support Services: Ment mentorship and resources for growth.
  • Learn more about NXTP Labs

7. ACE Startups

Location: Not specified, operates across Latin America
Description: ACE has established itself as a leading incubator for startups needing extensive product development assistance.
Key Benefits:
  • Mentorship: Provides thorough guidance during product development, sales, and marketing.
  • Startup Stage: Supports early-stage and scaling companies.
  • Networking Opportunities: Facilitates connections for potential co-founders and investors.
  • Discover ACE Startups
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8. Founder Institute

Location: Various cities in Latin America
Description: This global program is geared towards helping early-stage founders develop their companies.
Key Benefits:
  • Structured Program: Offers a methodical approach to startup creation.
  • Global Network: Provides access to a comprehensive network of mentors and founders.
  • Focus: Particularly beneficial for those in the ideation and early stages.
  • Check out Founder Institute

9. Antler Brazil

Location: Brazil
Description: Antler is a global startup generator and VC firm focused on early-stage ventures.
Key Benefits:
  • Investment: Offers significant funding to selected early-stage startups.
  • Support Network: Connects startups with a wide array of mentors and investor networks.
  • Focus Area: Highly supportive of innovative startups in emerging fields like AI.
  • Explore Antler Brazil

10. BootUp360 - Business Incubation Program

Location: South America
Description: A global business incubation platform providing integrated mentorship and resources.
Key Benefits:
  • Mentoring: A robust mentorship program connecting entrepreneurs globally.
  • Integrated Support: Comprehensive business incubation services customized for artificial intelligence startups.
  • Networking: Leverages a vast network of mentors to provide invaluable guidance.
  • Learn more about BootUp360

11. AI First Accelerator Program

Location: Spanish-speaking countries in Latin America
Description: A distinctive program specifically designed for AI-first startups looking to scale.
Key Benefits:
  • Targeted Support: Focused mentorship and resources tailored to AI technology.
  • Investment Opportunities: Provides funding for startups advancing AI innovation.
  • Community Access: Brings startups together with industry peers for collaboration.
  • Discover AI First Accelerator Program

12. Seedstars

Location: Various countries in South America
Description: A global network that aims to find and invest in the most promising early-stage startups.
Key Benefits:
  • Investment Range: Offers funding opportunities for high-potential startups.
  • Training Sessions: Provides tailored training for founders to develop their business models.
  • Networking Events: Hosts numerous events aimed at fostering connections among entrepreneurs.
  • Visit Seedstars

13. InovaBra

Location: Brazil
Description: A corporate innovation program designed to foster startups and collaborations with major corporations.
Key Benefits:
  • Corporate Collaboration: Connects startups with large corporations to drive innovation.
  • Investment Options: Provides pathways for investment in emerging startups.
  • Focus on Tech: Supports various tech niches, including artificial intelligence.
  • Learn about InovaBra

14. C40 Cities Climate Leadership Group

Location: Various cities in South America
Description: An incubator that promotes innovative climate technology solutions within urban settings.
Key Benefits:
  • Climate-Focused: Supports startups interfacing with AI solutions for climate issues.
  • Networking Opportunities: Connects startups with city leaders and industry experts.
  • Funding Opportunities: Offers grants and support for sustainable startup initiatives.
  • Discover C40 Cities Climate Leadership

15. Startupbootcamp

Location: Various locations across Europe and South America
Description: A global network of industry-focused startup accelerators dedicated to supporting innovative entrepreneurs.
Key Benefits:
  • Rapid Growth: Designed to accelerate startups to market quickly.
  • Funding and Resources: Provides financial support and access to a global network.
  • Sector Focused: Specializes in sectors including fintech, IoT, and AI.
  • Learn more about Startupbootcamp
This list provides a comprehensive view of the leading incubators and accelerators dedicated to fostering AI startups across South America in 2025. Each program brings unique advantages that can significantly benefit entrepreneurs in their journey toward innovation and commercialization.
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FAQ

Q: What is Start-Up Chile and its significance to AI startups?
A: Start-Up Chile is one of the largest startup incubators in Latin America, located in Santiago, Chile. It has accelerated nearly 2,000 startups with a total valuation of $2.1 billion and offers funding, mentorship, and access to a global network, making it a key resource for AI startups. Learn more about Start-Up Chile.
Q: How does Google for Startups Accelerator Brazil support AI startups?
A: Google for Startups Accelerator Brazil provides resources, mentorship, funding, and access to a global network, helping AI startups grow and innovate. Notably, it supports organizations utilizing AI with funding that ranges from $500k to $2M. Discover more about Google for Startups Accelerator.
Q: What is the role of Wayra in fostering AI startups?
A: Wayra, the startup accelerator of TelefĂłnica, operates in multiple South American countries and supports a wide range of technology startups, providing mentorship, networking opportunities, and potential funding. More information on Wayra can be found here.
Q: What does 500 Startups LatAm offer to AI startups?
A: 500 Startups LatAm is an early-stage investment fund that provides $60,000 in investments, mentorship, and a creative environment for startups, focusing on early-stage companies. Learn more about 500 Startups LatAm.
Q: How selective is the Mass Challenge accelerator program in Mexico?
A: Mass Challenge is very selective, accepting only about 5% of applications, and has accelerated 167 startups since 2016, raising a total of $132 million. It operates with a zero-cost, zero-equity model. Find out more about Mass Challenge.
Q: What is NXTP Labs' focus in the tech landscape?
A: NXTP Labs, with locations across various countries, targets innovative technology startups and provides resources, mentorship, and access to a network of entrepreneurs, including those working in AI. Explore NXTP Labs here.
Q: What kind of support does ACE Startups offer?
A: ACE Startups provides invaluable support for product development, sales, and marketing while aiding early-stage and scaling startups with mentorship and funding opportunities. Learn more about ACE Startups.
Q: What differentiates the Founder Institute's program for AI startups?
A: The Founder Institute focuses on early-stage founders and provides mentorship, a structured program, and access to a global network, making it ideal for those in the idea and early stages of their AI startups. Discover more about the Founder Institute.
Q: What investment opportunities does Antler Brazil provide?
A: Antler Brazil focuses on identifying exceptional talents and provides investment opportunities to selected startups, connecting them with investors and mentors targeting very early-stage companies. Learn more about Antler Brazil.
Q: How does BootUp360 support startups in South America?
A: BootUp360 is a global business incubation platform offering integrated mentorship and support to startups, with a focus on facilitating business growth through a global network of mentors. More about BootUp360 can be found here.

About the Author

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
2025-05-18 08:01 Top 15