Top 25 Incubators for Deep Tech Startups in North America in 2025
North America's deep tech startup ecosystem is fertile ground for innovation, and top-tier incubators are playing a vital role in nurturing next-generation technologies. These incubators provide funding, mentorship, and resources that are essential for the growth and success of deep tech startups. Here are the top 25 incubators to watch in 2025, ranked based on their influence, resources, and support structures.
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1. Y Combinator (YC)
Location: Mountain View, California
Focus: Open to all industries, with a strong emphasis on tech, including deep tech.
Investment: $500,000 ($125,000 for 7% equity + $375,000 uncapped SAFE)
Program Duration: 3 months
Notable Benefit: Access to a powerful alumni network, mentorship from industry leaders, and Demo Day exposure to top investors.
2. Techstars
Location: Global (with many programs in North America)
Focus: Diverse industries including health tech, fintech, and clean tech, with deep tech-specific programs.
Investment: $120,000 for 6% equity
Program Duration: 3 months
Notable Benefits: Hands-on mentorship, access to a global network of investors, and perks worth over $4 million.
3. SOSV
Location: Princeton, New Jersey, New York City, and other locations
Focus: Deep tech, life sciences, climate technology, hardware, and software.
Investment: Varies, typically $250K for 8% in some programs.
Program Duration: Varies by program.
Notable Programs: IndieBio (life sciences), HAX (hard tech).
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4. MassChallenge
Location: Boston, Massachusetts; other global locations
Focus: All industries, with strong support for deep tech and health tech.
Investment: Zero-equity in some programs, funding available
Program Duration: Varies by program
Notable Benefit: Global innovation ecosystem, mentorship, and access to resources
5. Plug and Play Tech Center
Location: Sunnyvale, California
Focus: Industry-specific innovation across 40+ sectors including fintech, health, mobility, and deep tech.
Investment: Varies (no equity requirement for some programs), $25k-$500k.
Program Duration: 12 weeks
Notable Benefits: Corporate partnerships, mentorship, and access to a global network.
6. Greentown Labs
Location: Somerville, Massachusetts
Focus: Clean technology startups, including renewable energy, sustainability, and environmental tech.
Facilities: Access to lab facilities and specialized equipment.
Community: A network of entrepreneurs dedicated to environmental impact.
Impact: Accelerating the transition to a sustainable economy.
7. RocketSpace
Location: Multiple locations
Focus: Wide range of technology industries, specializing in Foodtech, Mobility Tech, Agtech, Logistics Tech.
Program Duration: 6-month program
Program Structure: Two cohorts per year with 8 to 16 startups each
Graduation: 170 startups graduated as of Dec-17
8. IndieBio (SOSV)
Location: New York City, and other locations
Focus: Life sciences startups
Investment: $250K for 8% equity
Program Type: Science Startup Accelerator
9. HAX (SOSV)
Location: Shenzhen, Silicon Valley, and other locations
Focus: Hardware startups
Investment: $250K
Program Type: Venture Capital for Hardware
10. IBM Hyper Protect Accelerator
Location: Charlotte, North Carolina
Focus: Insurtech, Healthtech, and Fintech, supporting startups leveraging sensitive data
Investment: Up to $120,000 of free IBM Cloud credits
Program Structure: 40+ hours of virtual technical and business mentorship
Benefit: Investment-readiness and technical mentorship
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11. Nex Cubed
Location: San Francisco, California
Focus: Startups entering the US market
Investment: $25,000 for 6% equity
Program Duration: 3 to 6 months
Acceleration: Accelerated 300+ startups since inception
12. Point72 Ventures
Location: Stamford, Connecticut
Focus: Fintech, Deep Tech, and Enterprise investments
Stage: Every-stage global VC fund
Program: PointForward Summer - 12 week program for early stage energy and commodities companies
13. Entrepreneurs Roundtable Accelerator (ERA)
Location: New York, NYC
Focus: Tech startups
Program: NYC's leading tech accelerator
Mentorship: 400+ expert mentors
14. Alchemist Accelerator
Focus: Early stage B2B startups
Benefit: Provides mentorship, resources, and network
15. Deep Learning (NVIDIA Inception Program)
Location: Multiple locations
Focus: AI and data science sector
Support: Assistance with product development, prototyping & deployment, marketing, and more
Training: Offers training, workshops, mentorship, and networking opportunities
Founded: 1993
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16. Gener8tor
Focus: Various industries, platform includes 75+ programs
Mission: Opportunity for all
17. AngelPad
Focus: Early-stage startups with a focus on quality
Program Duration: 10-week program
18. HighTechXL
Location: Eindhoven, Netherlands
Focus: High-tech startups in deep tech, medtech, and energy
Support: Dedicated support in prototyping, scaling, and market entry
Impact: Fostering startups that make real global changes
19. Polsky Deep Tech Ventures (University of Chicago)
Focus: Translating innovations into startups
Program: Full-spectrum accelerator and venture support initiative
20. Duality (Quantum Accelerator)
Focus: Quantum startups
Program: First accelerator program in the US exclusively focused on quantum startups
21. Tech Ranch Austin
Location: Austin, Texas
Focus: Equipping entrepreneurs and ecosystems
Influence: Influenced more than 6,000 entrepreneurs in 42+ countries with more than 750 solutions deployed
Recognition: Recognized as a Top Social Impact Incubator and Top Accelerator in the US/Canada
22. Fintech Innovation Lab
Focus: Early to growth stage fintech companies
Program Duration: 12-week program
23. Capital Factory
Focus: Tech startups
Support: Provides mentorship, funding, and access to a network
24. Revtech Labs
Location: Charlotte
Focus: Fintech startups
Program Duration: 3 months
Investment: $40,000
25. The Yield Lab North America
Focus: Agtech startups
This list provides a solid starting point for exploring deep tech incubators in North America for 2025. Remember to always check the most up-to-date information on each organization's website, as programs and details can change.
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FAQ
Q: Which incubator is ideal for deep tech startups in North America?
A: Y Combinator (YC) in Mountain View, California is highly recommended. Apply to Y Combinator.
Q: What incubator has a strong emphasis on clean technology startups?
A: Greentown Labs in Somerville, Massachusetts focuses on clean technology startups. Learn about Greentown Labs.
Q: Which incubator provides global networking opportunities?
A: Techstars offers broad industry focus and access to a global network of investors. Apply to Techstars.
Q: What incubator caters specifically to life sciences startups?
A: IndieBio (SOSV) in New York City is perfect for life sciences startups. Discover IndieBio.
Q: Which incubator is located in Sunnyvale, California?
A: Plug and Play Tech Center is situated in Sunnyvale, California, catering to diverse tech sectors. Explore Plug and Play.
Q: What incubator focuses on hardware startups?
A: HAX (SOSV) is dedicated to hardware startups. Check out HAX.
Q: Which incubator supports startups in environmental and sustainability sectors?
A: Greentown Labs accelerates startups in renewable energy, sustainability, and environmental technology. Visit Greentown Labs.
Q: What incubator in Princeton, New Jersey focuses on deep tech?
A: SOSV has a presence in Princeton, New Jersey, and focuses on deep tech, life sciences, and climate technology. Learn about SOSV.
Q: Which incubator does not take equity in some programs?
A: MassChallenge in Boston, Massachusetts offers zero-equity programs. Discover MassChallenge.
Q: What incubator is majorly recognized for fintech startups?
A: Revtech Labs in Charlotte focuses on fintech startups.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
