Top 25 Angel Investors for Deeptech Startups in North America in 2025
As the arena of deeptech continues to evolve, strong backing from experienced angel investors is crucial for the success and scaling of startups in this domain. Here's a detailed look at the top 25 angel investors focusing on deeptech startups in North America for the year 2025. Each investor carries unique strengths, expertise, and networks that set them apart.
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1. Marc Andreessen
Marc Andreessen, a co-founder of Netscape and Andreessen Horowitz, leverages his wealth of experience in software and networking technologies. He is heavily involved in AI, machine learning, and biotechnology startups.
2. Amit Karp
Amit Karp brings a robust background in AI and robotics, with investments in several early-stage deeptech startups. His expertise helps startups navigate the complexities of launching in these fields.
3. Daniel Ek
Known widely as the co-founder of Spotify, Daniel Ek has turned his focus towards deeptech investment. He looks for innovative solutions in advanced technologies, such as new materials, biotechnology, and AI.
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4. Life Science Angels
Life Science Angels specialize in biotechnology and healthcare. They offer substantial strategic guidance along with their funding, making them a key player in deeptech investments.
5. Lux Capital
With an AUM of $5B, Lux Capital invests in far-reaching sectors including advanced materials, space technology, and AI. They provide ample resources for scaling deeptech startups.
6. 83North
83North is an early-stage investor known for its focus on AI, robotics, and health tech. They offer investments ranging from $100k to $1M, providing crucial early-stage capital.
7. Accel
Accel is renowned for funding transformative companies in their seed to Series D stages. They focus heavily on AI, cloud computing, and cybersecurity.
8. SOSV
SOSV invests in deep technology sectors through its HAX accelerator. Areas of interest include hardware, AI, and biotech.
9. Trinity Ventures
Trinity Ventures, with $2.2B in funds, focuses on AI-driven platforms and enterprise software. Their deep networks in Silicon Valley add tremendous value to the startups they fund.
10. Main Sequence Ventures
Based in Australia but active in North America, Main Sequence Ventures focuses on companies that use AI and robotics to improve various industries, such as food and agriculture.
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11. Riot Ventures
Riot Ventures backs startups in AI, machine learning, and robotics. They believe in hands-on mentorship and bringing strategic partnerships to their portfolio companies.
12. Bezos Expeditions
Jeff Bezos's personal investment company focuses on technological advancements in space exploration, AI, and quantum computing, offering significant strategic advantages.
13. Walden Catalyst
Walden Catalyst is driving innovation in deep learning and computer vision. They support startups through mentorship and strategic guidance beyond capital investment.
14. Atlantic Bridge Ventures
Primarily investing in AI and semiconductors, Atlantic Bridge Ventures focuses on scaling companies globally from their bases in North America and Europe.
15. M Ventures
M Ventures, the venture arm of Merck, is deep into biotechnology and life sciences. They support startups with unmatched resources and strategic synergies.
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16. K9 Ventures
Investing in seed and early-stage companies, K9 Ventures supports breakthroughs in AI and robotics. Their founder-centric approach provides robust developmental support.
17. Embark Ventures
Embark Ventures focuses on deep tech in AI, cybersecurity, and life sciences. Their investments help bridge the gap between groundbreaking research and commercial viability.
18. Sandpiper Ventures
With a keen eye on Health Tech, Sandpiper Ventures leverages their deep industry connections to support and scale promising startups in technology-driven sectors.
19. OpenAI Startup Fund
The OpenAI Startup Fund supports companies that align with their mission to advance digital intelligence responsibly, covering fields from AI to ethical tech.
20. Founders Fund
Founders Fund is known for taking bold bets on frontier technology. Their portfolio includes companies in AI, advanced materials, and space technologies.
21. Good Growth Capital
Good Growth Capital focuses on scalable high-tech companies in sectors including IoT, AI, and clean energy. Their extensive due diligence ensures impactful investments.
22. Fly Ventures
Fly Ventures focuses on early-stage deeptech startups across AI, robotics, and clean technology. They provide extensive resources and networks that crucially benefit growing companies.
23. Sequoia Capital
Sequoia Capital has made significant investments in AI and lifecycle technology. Their global reach and venture expertise make them a formidable partner for any deeptech startup.
24. Authentic Ventures
Authentic Ventures dedicate their focus to innovative solutions in AI, IoT, and digital healthcare with the mission to back diverse and inclusive teams.
25. Supernova Invest
Supernova Invest focuses on investments in quantum technologies, advanced materials, and semiconductors. Their portfolio companies benefit from strategic guidance and domain expertise.
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FAQ
Q: Who are some of the top Deep Tech investors in North America for 2025?
A: Prominent investors include Riot Ventures, Grove Ventures, and Good Growth Capital. Learn more here.
Q: What investment stages are focused on by leading Deep Tech investors?
A: Most Deep Tech investors target stages like Seed, Early-stage, and Growth. Check more details here.
Q: Which investor has a significant presence in biotechnology for deep tech startups?
A: Lux Capital is well-known for its presence in biotechnology investments. Find out more here.
Q: Which locations are deep tech investors focusing on in 2025?
A: Although companies are spread globally, US and China are notable leaders in deep tech investments. Check the detailed analysis.
Q: Are there any specific angel networks supporting deep tech startups?
A: Yes, several networks provide support and funding, such as Deeptech Angels. Discover more here.
Q: Which sectors are gaining more attention from deep tech investors?
A: Sectors like AI, quantum computing, and biotechnology are among the most targeted areas. Read in-depth here.
Q: Are there any investor programs combining funding and mentorship?
A: Yes, platforms like Deeptech Angels offer funding, acceleration, mentorship, and workshops supportive of the entire investment lifecycle. More about the program here.
Q: Which investor focuses on AI and generative models in deep tech?
A: Maria Rotilu from OpenseedVC is known for her focus on AI, generative, and agent models. Learn about her investments.
Q: Are there any European investors actively investing in deep tech?
A: Yes, notable investors in Europe include Atomico and Balderton Capital. More information on their focus.
Q: What additional value can angel investors offer beyond funding?
A: Besides funding, angel investors can offer strategic guidance, mentorship, and valuable resources to help startups thrive.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
