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BEST 10 Startups in San Juan, Puerto Rico in 2025: A MUST-HAVE Guide for Entrepreneurs

San Juan, Puerto Rico, is buzzing with innovation in 2025, establishing itself as one of the most exciting startup ecosystems in the Americas. With its entrepreneurial flair and a growing investment landscape, the city boasts an impressive lineup of high-growth startups across fintech, e-commerce, AI, and more. From emerging leaders like BrainHi to global disruptors like Zenus Bank, these startups are not only solving local challenges but are also gaining international praise.

Whether you're an entrepreneur, investor, or just curious about the opportunities this U.S. territory offers, this guide is your golden ticket to understanding San Juan's thriving startup community. Let's dive into the best 10 startups that are shaping the future in 2025!

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Why Puerto Rico Is Booming as a Startup Hub

Puerto Rico's financial incentives (like Act 60), vibrant culture, and strategic location make it a magnet for entrepreneurs. From access to U.S. markets to its attractive corporate tax rate, the island provides a unique combination of opportunity and affordability. On top of this, Puerto Rico’s startup ecosystem has been growing steadily. According to a report by StartupBlink, Puerto Rico has experienced 24.8% ecosystem growth since 2019, with sectors such as fintech, software, and sustainable technology leading the charge.

One of the most exciting upgrades in Puerto Rico is its focus on fostering grassroots entrepreneurship. Initiatives like the Bravo Family Foundation's Venture Fellowship Program are equipping startups with equity funding and mentorship, ensuring early-stage founders build sustainable businesses.

Top 10 Startups in San Juan to Watch in 2025

1. BrainHi

BrainHi is revolutionizing business communication with its AI-powered assistant for appointment scheduling and customer service. Targeted at the healthcare and small business sectors, BrainHi is becoming an indispensable tool for improving customer engagement and operational efficiency.

Highlight: Raised $4 million in 2024 to expand AI capabilities.
Why It Matters: Proven to reduce missed appointments by 30%.

2. Zenus Bank

Zenus Bank aims to create a borderless banking experience by making international financial transactions seamless. With its easy-to-use digital platform, it's spearheading fintech growth across Latin America and beyond.

Highlight: Raised a $25 million Series C in January 2025 to scale operations into Africa.
Why It Matters: Named Puerto Rico’s fastest-growing fintech by StartupBlink.

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3. Skootel

Skootel is Puerto Rico’s leading micromobility startup, providing electric scooters to reduce urban congestion and pollution. Its user-centered design and real-time fleet tracking make it an urban commuter's dream.

Highlight: Expanded to five new cities in 2025.
Why It Matters: Contributes to Puerto Rico’s efforts to lower carbon emissions by 8% annually.

4. Abartys Health

Abartys Health bridges healthcare providers, insurers, and patients through its cutting-edge, data-intelligent platform. By improving transparency in healthcare, the platform is transforming how Puerto Ricans access medical care.

Highlight: Closed a $6 million funding round in Q2 2025 for AI-based analytics development.
Why It Matters: Reduced insurance claim processing times by 50%.

5. Brands of Puerto Rico

Brands of Puerto Rico empowers local artisans and small businesses by providing them with an e-commerce platform to sell globally. The company has become a cornerstone of Puerto Rico’s handmade goods economy.

Highlight: Partnered with Etsy in 2025 to expand the reach of Puerto Rican products across Europe.
Why It Matters: Supports over 200 small businesses on the island.

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6. Evertec

Evertec creates secure payment processing solutions for businesses in Latin America and the Caribbean. With services from point-of-sale systems to blockchain-based payment integration, Evertec is leading the shift towards cashless transactions.

Highlight: Partnering with Visa for blockchain cross-border payments.
Why It Matters: Processes transactions worth $35 billion annually.

7. Wovenware

Specializing in AI and data science, Wovenware delivers tailored technology solutions for various industries, from healthcare to manufacturing. Their work combines innovation with real-world practicality.

Highlight: Acquired by Maximus in 2024, bringing heavy investments into Puerto Rico.
Why It Matters: Employs over 150 people locally, empowering the tech workforce.

8. Aquamatic Solutions

This startup focuses on water purification and conservation tech, addressing Puerto Rico's ongoing water supply challenges. Their patented device uses solar energy to desalinate water.

Highlight: Won Puerto Rico’s Green Innovation Award in 2025.
Why It Matters: Provides clean water to over 20,000 underserved households.

9. Caribe Compostables

A sustainability-focused startup, Caribe Compostables produces eco-friendly packaging alternatives to reduce waste. Their robust R&D team constantly pioneers innovative compostable materials.

Highlight: Secured a $1.5 million grant to scale biodegradable product development.
Why It Matters: Eliminates 10 tons of non-biodegradable waste monthly.

10. ConnectDH

ConnectDH strives to eliminate communication barriers in healthcare by facilitating direct and secure messaging between providers and patients via its mobile application.

Highlight: Adopted by Puerto Rico’s largest healthcare network in 2025.
Why It Matters: Improved medication adherence rates by 15%.

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How To Validate Your Startup Idea Before Building

Most entrepreneurs make the mistake of diving into product development without validating their idea. Marketing is harder than building the product, especially in 2025's hyper-competitive landscape. This is where startups can take advantage of tools like the AI SEO Blog tool, designed specifically for entrepreneurs looking to validate their idea.

By ranking your blog or idea on Google and AI-based platforms like ChatGPT or Perplexity, you can measure customer interest before investing heavily in development. From deep keyword research to automated content creation, tools like these let you gather actionable insights and establish early traction.

Common Mistakes Startups Should Avoid

Skipping Market Research: Too many startups jump in blind.
Overlooking Customer Retention: Gaining users without keeping them is a death trap.
Neglecting Marketing: Ensure your audience knows you exist!

For a deep dive into AI-powered marketing assistance, services like F/MS Marketing Services are invaluable. From securing high-quality backlinks to gaining visibility in AI search networks, such tools provide a significant edge.

Conclusion

San Juan, Puerto Rico, is more than just a hub of cultural richness, it's becoming a tech titan in the Caribbean. The top 10 startups in 2025 showcase the island's ability to nurture businesses that solve global problems while supporting the local economy.

If you're an entrepreneur looking for inspiration or a potential collaborator, these startups are worth keeping on your radar. And if you aim to validate your idea and grow visibility in this ecosystem, tools like the AI SEO Article Writer can take you from concept to scale efficiently.

Get ready to dive into Puerto Rico's electric startup scene, where innovation sparks global change! What excites you the most about San Juan’s startups? Let us know in the comments!

FAQ on the Best Startups in San Juan, Puerto Rico in 2025

1. Why is San Juan gaining popularity as a startup hub?

San Juan is becoming a vibrant startup hub due to financial incentives like Act 60, a growing investment ecosystem, and its unique combination of U.S. market access with affordable living costs. Key sectors driving this growth include fintech, e-commerce, and sustainable technology. Learn more about San Juan’s startup growth

2. Where can I submit a guest post about my startup?

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3. Which startups are leading San Juan’s fintech sector?

Startups like Zenus Bank and Evertec are leading the fintech sector. Zenus Bank focuses on borderless banking for international transactions, while Evertec leads the shift to cashless transactions with secure payment solutions. Explore Zenus Bank

4. What micromobility solutions are startups in Puerto Rico offering?

Skootel is a standout in micromobility, offering electric scooters to reduce urban congestion and carbon emissions. Learn more about Skootel

5. How are startups addressing Puerto Rico's sustainability challenges?

Startups like Caribe Compostables and Aquamatic Solutions are tackling environmental challenges. Caribe Compostables focuses on eco-friendly packaging, while Aquamatic Solutions provides solar-powered water desalination. Both are making a significant impact on sustainability.

6. Are there AI-focused startups in San Juan?

Yes, BrainHi and Wovenware are notable AI-focused startups. BrainHi specializes in AI-powered communication tools, while Wovenware offers data science and custom AI solutions. Discover BrainHi

7. Can I use AI to write SEO-optimized articles that help my brand grow?

Most business owners don't understand how SEO works, let alone how to use AI for writing blog articles. That's why for busy business owners there's a great free tool that doesn't require much knowledge. Write articles for free

8. What e-commerce opportunities are startups in Puerto Rico offering?

Brands of Puerto Rico is revolutionizing e-commerce by empowering local artisans to sell their products globally. Learn more about Brands of Puerto Rico

9. How are startups transforming healthcare in Puerto Rico?

Abartys Health and ConnectDH are leading the way in healthcare transformation. Abartys Health improves healthcare data transparency, while ConnectDH enables secure messaging between patients and providers.

10. Are there programs supporting early-stage startups in Puerto Rico?

Yes, initiatives like the Bravo Family Foundation’s Venture Fellowship Program provide equity funding and mentorship to early-stage startups. These programs are instrumental in nurturing grassroots entrepreneurship. Check out the Bravo Family Foundation

About the Author

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.

Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).

She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.

For the past several years Violetta has been living between the Netherlands and Malta, while also regularly traveling to different destinations around the globe, usually due to her entrepreneurial activities. This has led her to start writing about different locations and amenities from the POV of an entrepreneur. Here’s her recent article about best hotels in Italy to work from.

About the Publication

Fe/male Switch is an innovative startup platform designed to empower women entrepreneurs through an immersive, game-like experience. Founded in 2020 during the pandemic "without any funding and without any code," this non-profit initiative has evolved into a comprehensive educational tool for aspiring female entrepreneurs.The platform was co-founded by Violetta Shishkina-Bonenkamp, who serves as CEO and one of the lead authors of the Startup News branch. The Fe/male Switch team is located in several countries, including the Netherlands and Malta.

Mission and Purpose

Fe/male Switch Foundation was created to address the gender gap in the tech and entrepreneurship space. The platform aims to skill-up future female tech leaders and empower them to create resilient and innovative tech startups through what they call "gamepreneurship". By putting players in a virtual startup village where they must survive and thrive, the startup game allows women to test their entrepreneurial abilities without financial risk.

Key Features

The platform offers a unique blend of news, resources,learning, networking, and practical application within a supportive, female-focused environment:

Skill Lab: Micro-modules covering essential startup skills
Virtual Startup Building: Create or join startups and tackle real-world challenges
AI Co-founder (PlayPal): Guides users through the startup process
SANDBOX: A testing environment for idea validation before launch
Wellness Integration: Virtual activities to balance work and self-care
Marketplace: Buy or sell expert sessions and tutorials

Impact and Growth

Since its inception, Fe/male Switch has shown impressive growth:

3,000+ female entrepreneurs in the community
100+ startup tools built
5,000+ pieces of articles and news written

Partnerships

Fe/male Switch has formed strategic partnerships to enhance its offerings. In January 2022, it teamed up with global website builder Tilda to provide free access to website building tools and mentorship services for Fe/male Switch participants.

Recognition

Fe/male Switch has received media attention for its innovative approach to closing the gender gap in tech entrepreneurship. The platform has been featured in various publications highlighting its unique "play to learn and earn" model.

Violetta Bonenkamp

2025-09-14 07:45 Best Startups