Top 20 VCs for Deeptech Startups in North America in 2025
As we progress into 2025, the venture capital landscape for deep tech startups in North America continues to evolve dramatically. Notably, the focus on deep technology—encompassing fields like artificial intelligence, biotech, and advanced materials—has become increasingly prominent within the VC community. This article highlights the Top 20 Venture Capitalists (VCs) leading the charge in funding deep tech ventures this year.
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1. Andreessen Horowitz (a16z)
Focus: Broad technology investments including AI, Biotech, and other deep tech sectors.
Stage: Multiple stages, from early-stage to growth.
Portfolio: Backed successful tech companies such as Airbnb, Instacart, and OpenAI.
AUM: Significant assets under management, providing ample capital for deep tech initiatives.
Data Points: Based in Silicon Valley with a large fund size and a powerful network, a16z excels at scaling companies.
2. Sequoia Capital
Focus: Investment across a broad range of tech sectors, prominently deep tech.
Stage: Multiple stages from early to growth.
Portfolio: Reputable for supporting tech giants such as Apple, Google, and Oracle.
AUM: Very significant AUM with an impressive track record of successful investments.
Data Points: Known for its global network and deep industry insights, contributing to long-term successes.
3. SOSV
Focus: Global deep tech venture capital with a specific emphasis on human and planetary health.
Stage: Early-stage, including seed and Series A.
Portfolio: Includes over 200 early-stage deep tech ventures, with a track record of 8 unicorns and 58 IPOs through HAX and IndieBio programs.
AUM: $1.5B+ AUM.
Data Points: Known for its global reach and specialized support programs for startups.
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4. Lux Capital
Focus: Early-stage investments concentrated on AI, biotech, and neuroscience.
Stage: Early-stage.
Portfolio: Investments include companies like Airmap, Aeva, and Eikon Therapeutics.
AUM: $5B+ AUM.
Data Points: Established expertise in deep tech and a robust network assist Lux in fostering highly innovative enterprises.
5. Founders Fund
Focus: Technology-focused, notable for investing in radical and innovative companies.
Stage: Multiple stages.
Portfolio: Backed high-profile companies like SpaceX and Palantir.
AUM: Large fund size.
Data Points: Known for making contrarian bets and has substantial experience in scaling disruptive technologies.
6. Khosla Ventures
Focus: Targeting technology investments in cleantech, health, and enterprise sectors.
Stage: Early to growth stages.
Portfolio: Notable investments include 23andMe and Helion Energy.
AUM: Significant fund size with strong backing.
Data Points: Focused on impactful technology with significant capital to support visionary founders.
7. Accel
Focus: Investments in early and growth-stage tech sectors, including Health Tech and Climate Tech.
Stage: Pre-seed to growth stages.
Portfolio: Includes successful companies like Slack and Facebook.
AUM: Significant fund size supporting a diverse portfolio.
Data Points: Global reach and a long history of backing successful ventures underscore its market influence.
8. Y Combinator
Focus: A prominent early-stage startup accelerator heavily engaged with deep tech.
Stage: Seed stage.
Portfolio: Fostered early-stage investments in companies like OpenAI and Matterport.
AUM: Significant fund size.
Data Points: Recognized for its extensive portfolio of deep tech companies and robust community support.
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9. Boost VC
Focus: Early-stage deep tech ventures with a specific emphasis on pre-seed startups.
Stage: Primarily pre-seed stage.
Portfolio: Invests across aerospace, AI/ML, VR/AR, and more.
AUM: $200 million AUM.
Data Points: Known for early-stage funding, focusing on innovative solutions in multiple tech domains.
10. Ocean Azul Partners
Focus: Investments in B2B software and deep tech across various sectors.
Stage: Early stage.
Portfolio: Actively involved in their portfolio companies, often taking board seats.
AUM: Initial investments range from $200K to $2M.
Data Points: Specifically targets North America with rigorous product qualification.
11. ff Venture Capital
Focus: Seed and early-stage investments.
Stage: Seed and early stage.
Portfolio: High-performance focus on seed-stage ventures.
AUM: Not specified.
Data Points: Based in New York with a strong emphasis on early-stage investments across multiple tech sectors.
12. Alumni Ventures
Focus: A diversified portfolio of deep tech investments.
Stage: Seed to Series B.
Portfolio: Concentrated on early-stage deep tech startups.
AUM: Not specified.
Data Points: Located in New Hampshire, they maintain a diverse investment approach often in industry-shaking technologies.
13. D.C. Ventures
Focus: Early-stage venture capital with advisory services for startups.
Stage: Early stage.
Portfolio: Strong emphasis on deep tech startups.
AUM: Not specified.
Data Points: Located in Washington D.C., they provide advisory services alongside investments.
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14. Eniac Ventures
Focus: Seed funding across various tech sectors.
Stage: Seed.
Portfolio: Diverse investments including B2B, Consumer, and Web3.
AUM: Not specified.
Data Points: Located in San Francisco, Eniac is known for their emphasis on seed funding in tech drives.
15. Two Sigma Ventures
Focus: Early-stage investments in the tech sector.
Stage: Early stage.
Portfolio: Not specifically disclosed.
AUM: Not specified.
Data Points: Based in New York, they concentrate on early-stage deep tech companies.
16. Cottonwood Technology Fund
Focus: Hard sciences and deep tech companies.
Stage: Seed, Series A.
Portfolio: Includes companies like BayoTech and BioFlyte.
AUM: Not specified.
Data Points: Based in New Mexico and focused on startups with intellectual property potential.
17. Plug and Play Tech Center
Focus: Broad tech investments including deep tech ventures.
Stage: Multiple stages.
Portfolio: Includes companies such as Chainalysis and Ouster.
AUM: Not specified.
Data Points: Extensive portfolio with a strong presence in the startup ecosystem.
18. MassChallenge
Focus: Startup accelerator encompassing various technology areas, including deep tech.
Stage: Early stage.
Portfolio: Companies such as Strand Therapeutics and Voxel8.
AUM: Not specified.
Data Points: Recognized for their accelerator program and strong investor networks.
19. Techstars
Focus: Startup accelerator with investments in various tech sectors, including deep tech.
Stage: Early stage.
Portfolio: Includes Chainalysis and Sphero.
AUM: Not specified.
Data Points: Known for its extensive support for deep tech and strong connections to investors.
20. OpenAI Startup Fund
Focus: Early-stage companies in advanced tech fields, specifically AI and robotics.
Stage: Series A.
Portfolio: Limited investments but significant in tech innovation.
AUM: Not Specified.
Data Points: Targets transformative technologies without limiting check sizes, aiding pioneering companies.
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FAQ
Q: What types of startups do Andreessen Horowitz primarily invest in?
A: Andreessen Horowitz focuses on broad technology investments, including AI, biotech, and other deep tech sectors. Learn more about Andreessen Horowitz.
Q: Which VC has a strong track record of successful investments in technology giants?
A: Sequoia Capital has backed major tech companies such as Apple, Google, and Oracle, showcasing its long history of success. Discover Sequoia Capital.
Q: What is the investment focus of SOSV?
A: SOSV specializes in early-stage investments in deep tech with a focus on human and planetary health, supporting a range of startups. Learn about SOSV.
Q: What types of companies does Lux Capital invest in?
A: Lux Capital primarily makes early-stage investments in sectors like AI, biotech, and neuroscience, targeting innovative startups. Explore Lux Capital.
Q: Which venture capital firm is known for backing bold and innovative technologies?
A: Founders Fund is recognized for its technology focus and has invested in disruptive companies like SpaceX and Palantir. Find out more about Founders Fund.
Q: What sectors does Khosla Ventures prioritize in its investments?
A: Khosla Ventures focuses on cleantech, health, and enterprise sectors, aiming to back impactful technology companies. Learn more about Khosla Ventures.
Q: Which venture capital firm actively engages in its investments?
A: Ocean Azul Partners engages actively in their investments and typically holds board seats in their portfolio companies. Discover Ocean Azul Partners.
Q: What is Y Combinator's approach to investing in startups?
A: Y Combinator is a startup accelerator that invests heavily in early-stage deep tech, providing funding and mentorship to developing companies. Learn about Y Combinator.
Q: Which venture capital firm specializes in seed and early-stage investments?
A: ff Venture Capital focuses on seed and early-stage funding, showing a strong emphasis on nurturing new ventures. Explore ff Venture Capital.
Q: What does the OpenAI Startup Fund focus on when evaluating companies?
A: The OpenAI Startup Fund concentrates on early-stage companies in advanced technology fields such as AI and robotics, without limiting check sizes. Learn more about OpenAI Startup Fund.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
