Top 10 Countries for Deeptech Startups in North America in 2025
As the landscape for deeptech innovation continues to evolve, 2025 is set to witness significant advancements across several nations in North America. This region is emerging as a hotbed for cutting-edge technologies, including AI, quantum computing, and clean energy solutions. Below is a deep dive into the Top 10 Countries for Deeptech Startups in North America in 2025, based on insights and data from various sources.
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1. United States
Key Cities: San Francisco, New York, Boston, Los Angeles, Austin
Investment Trends: The U.S. is anticipated to maintain its lead as a prime destination for deeptech startups due to its robust venture capital ecosystem. San Francisco remains at the forefront with a plethora of investors focusing on breakthrough technologies in areas like AI and biotech. In 2025, a surge in mega-deals is predicted, particularly for "unicorns" (startups valued over $1 billion).
Challenges: Despite potential growth, deeptech investments with longer timelines might face a setback due to a decrease in risk appetite among investors.
2. Canada
Key Cities: Toronto-Waterloo, Montreal, Vancouver
Investment Trends: Canada is becoming increasingly significant in the deeptech realm, with a focus on AI and sustainability. The Toronto-Waterloo corridor is a hub for innovation, emerging as a favorite for both startups and investors. Events like DeepTechCon illustrate the thriving ecosystem fostering deeptech advancement.
Challenges: Investor presence is growing, but the scale of funding still trails behind the U.S.
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3. Mexico
Key Cities: Mexico City, Guadalajara
Investment Trends: Mexico's deeptech scene is fast-growing, particularly in industries like fintech and e-commerce. Unique funding opportunities and a vibrant startup culture make it a competitive landscape within the region. Over the next few years, further development in AI and blockchain could position Mexico as a noteworthy player.
Challenges: Infrastructure and regulatory hurdles may affect growth potential.
4. Puerto Rico
Key Cities: San Juan
Investment Trends: Puerto Rico stands out for its strategic location and tax incentives, making it a favorable ground for tech startups. The focus is shifting toward clean energy solutions. Initiatives promote startup growth, especially in technology related to sustainability and renewable energy sources.
Challenges: Economic instability can pose challenges for investor confidence.
5. Cuba
Key Cities: Havana
Investment Trends: While still developing, Cuba's focus on innovation in biotechnology and software development positions it as an emerging contender in the deeptech space. Recent regulations easing foreign investments could open new avenues for startups.
Challenges: Internet access and infrastructures remain significant barriers to innovation.
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6. Costa Rica
Key Cities: San José
Investment Trends: Known for its emphasis on environmental sustainability, Costa Rica has seen growth in green tech and clean energy startups. Government initiatives fostering technology transfer and innovation ecosystems bode well for emerging businesses.
Challenges: Limited access to funding compared to larger neighbors may hinder rapid growth.
7. Panama
Key Cities: Panama City
Investment Trends: With strong financial and logistical systems, Panama is a developing player in deeptech focused on logistics and blockchain technology. The government’s push for innovation incentives is expected to attract foreign direct investment.
Challenges: Political issues may affect the business landscape.
8. Jamaica
Key Cities: Kingston
Investment Trends: Jamaica's push towards digitization and tech education has spurred a budding startup environment focused on fintech and agri-tech innovations. The future prospects of AI applications within agriculture are notable.
Challenges: Limited resources and infrastructure may present hurdles for deeptech scaling.
9. Honduras
Key Cities: Tegucigalpa
Investment Trends: While currently not as prominent, Honduras shows potential in agricultural technology and software development. Startups focusing on local issues, such as agriculture and energy efficiency, are gaining traction.
Challenges: A tumultuous political climate can deter foreign investments.
10. Dominican Republic
Key Cities: Santo Domingo
Investment Trends: The Dominican Republic has a burgeoning technology sector, especially in IT services and mobile applications. Infrastructure improvements and interest in tech innovation may provide a fertile ground for startups.
Challenges: Many startups still face issues related to funding and scale.
The deeptech ecosystem in North America is rapidly changing, with various countries contributing uniquely to its growth. Each region is cultivating an environment conducive to innovation through investments in technology and supportive policies.
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FAQ
Q: Which country is considered the leader in deep tech startups in North America?
A: The United States is recognized as the leading country for deep tech startups in North America, with significant activity in cities like San Francisco, New York, and Boston. Learn more about deep tech investment trends.
Q: What is a major trend affecting deep tech funding in 2025?
A: A notable trend is the predicted surge in mega-deals involving unicorns (startups valued at $1B+) despite a general slowdown in deep tech investments. Discover more about funding trends.
Q: What significant investment program was announced for clean energy in 2025?
A: A $25 billion strategic investment program by DeepGreenX and Sente Ventures aims to revolutionize clean energy, focusing on generation, storage, and data centers. Read more about the investment program.
Q: What types of technologies are top investors focusing on in deep tech?
A: Top investors are targeting breakthrough technologies, particularly in AI, robotics, and advanced materials. View the list of investors.
Q: Which city is hosting a major deep tech event in 2025?
A: San Francisco will host "DeepTechCon," a premier event focusing on AI, quantum computing, and biotech, offering numerous networking opportunities. Learn more about DeepTechCon.
Q: How is climate tech impacting deep tech investment?
A: There is a growing investment momentum in climate tech, driven by increased interest from governments and corporations, highlighting its significance within the deep tech sector. Explore climate tech trends.
Q: What is the focus of the NRF 2025 event in New York?
A: The NRF 2025 event will feature innovation in retail tech, showcasing over 1,000 exhibitors and nearly 90 cutting-edge companies. Find out more about NRF 2025.
Q: What does the tech conference landscape look like in 2025?
A: Numerous tech conferences across cities like Atlanta and Austin will focus on deep learning, AI, and product management, indicating a concentration of tech activity in the U.S. See the list of tech conferences.
Q: Are there specific regions in Canada noted for deep tech activity?
A: Yes, regions such as Toronto-Waterloo, Montreal, and Vancouver are highlighted for their growing deep tech ecosystems. Learn about deep tech investment in Canada.
Q: What role do VC firms play in the deep tech startup ecosystem?
A: VC firms are critical in funding startups at various stages, focusing on cutting-edge technologies and providing mentorship to drive innovation. Explore the list of VC firms.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
