Top 10 STARTUPS in Sacramento to WATCH in 2025: Innovation Driving Growth
2025 is proving to be a landmark year for Sacramento’s startup ecosystem. Known for its affordability compared to Silicon Valley and its growing pool of talented innovators, this city is rapidly becoming a rising star in the United States tech scene. Whether you're an entrepreneur, investor, or startup enthusiast, Sacramento's thriving community has no shortage of fascinating businesses to follow.
From disrupting education tech to advancing healthcare, Sacramento-based startups are embracing innovation and solving real-world problems. Here's a curated list of 10 top startups making waves in Sacramento this year, reflecting a diverse lineup of industries and groundbreaking solutions.
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The Rise of Sacramento as a Startup Powerhouse
Why is Sacramento gaining prominence in the startup world? The city has developed a fertile environment for startups, thanks to investments, government-backed grants, and the support of tech hubs like UC Davis and FastTrac. In 2025, Sacramento launched $450,000 worth of grants to fuel entrepreneurship, which has spurred the creation of new tech jobs and brought over 1,400 tech companies to the region.
What makes it stand out? Sacramento is not just another Silicon Valley alternative, its focus on fostering innovation across sectors like clean energy, biotech, information technology, and AI has made it a dynamic ecosystem for startups.
1. PowerSchool - Revolutionizing EdTech
PowerSchool, one of the major players in education technology, continues to thrive in 2025. Their latest innovations, such as the PowerBuddy AI solutions, are designed to personalize learning experiences and empower educators with real-time insights into student performance. They aim to bridge the digital gap in education, making them a leader in transforming how schools operate.
2. Rhombus Systems - A Leader in IT Services
Rhombus Systems has earned its spot as a top Sacramento startup with its innovative security and surveillance solutions. They completed a Series C funding round in 2024, solidifying their plans to scale operations. Their AI-driven technologies help businesses enhance security while minimizing costs, a crucial service in today’s hyper-connected age.
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3. Eureka Health - Advancing Healthcare R&D
Eureka Health is making strides in healthcare research by introducing tools that enhance patient data analysis and medical workflows. By leveraging AI and machine learning, they’re optimizing clinical decisions and providing insights for personalized medication, initiatives that are truly life-changing.
For startups like Eureka Health, marketing is as essential as innovation. If you’re building a healthcare startup, leveraging tools like the AI SEO Blog can skyrocket your visibility and rankings on Google, ensuring your product gains the recognition it deserves.
4. Digestiva - Pioneering Bio Research
Digestiva is creating waves in the biotech space by focusing on the gut microbiome. With Series A funding secured in mid-2024, they’re expanding their groundbreaking research into areas like probiotics and targeted treatments for digestive health, a crucial field as consumers increasingly prioritize wellness.
5. Scooly - Empowering Flexible Learning
Scooly is another rising EdTech star, aiming to disrupt traditional learning models by embracing flexibility and personalization, from K-12 education to higher learning. They've just closed a pre-seed funding round in March 2025, promising to scale their innovative offerings further. This is definitely a startup to watch as education tech continues to soar.
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6. Nivagen Pharmaceuticals - Reshaping Pharma
Nivagen Pharmaceuticals specializes in manufacturing cost-effective generic drugs, helping to reduce healthcare costs for patients nationwide. Their cutting-edge methodologies and commitment to affordability make a solid case for why they are one of Sacramento's most significant contributions to the biotech scene.
7. Futuro Health - The Workforce Builder
Futuro Health is driving change by closing skill gaps in healthcare staffing. Their focus on career training and workforce development is crucial in addressing real issues in a sector struggling with shortages. By making resources and education more accessible, Futuro Health is helping bridge critical gaps in healthcare systems.
8. Infinium - Innovating IT Services
Infinium has created scalable IT infrastructures that are revolutionizing how companies manage their digital demands. By focusing on cloud optimization and network security, Infinium is paving the way for the future of IT services, especially as hybrid work models become the new norm.
9. Acorn Finance - Transforming Home Improvement Financing
Acorn Finance redefines home improvement financing with its easy-to-use platform that connects consumers with lenders. They’ve capitalized on solving a niche problem by focusing on a customer-first approach, earning a spot among Sacramento's most watched startups for 2025.
10. One.bio - Clean Energy’s Rising Star
One.bio takes an environmental focus, providing data-driven clean energy solutions. As cities and businesses race toward sustainability goals, One.bio’s impact can already be felt in reshaping global clean energy consumption.
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Why Startups Should Prioritize Marketing
It’s tempting to focus solely on product development in the initial stages, but the reality is marketing can make or break your startup. Many Sacramento startups have thrived because of their ability to communicate their value propositions effectively.
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Lessons from Sacramento’s Startups
What can we learn from Sacramento’s best startups in 2025?
- Solve Specific Problems: From healthcare to clean energy, these companies focus on niche challenges with high impact.
- Leverage Local Resources: Sacramento’s tech hubs, government grants, and support networks have been instrumental in their growth.
- Get Your Marketing Right: Using SEO strategies like AI-driven blogs can help new businesses go from unknown to indispensable.
Conclusion
Sacramento’s startup ecosystem in 2025 offers both inspiration and opportunities for entrepreneurs looking to grow innovative ventures. Companies like PowerSchool, Rhombus Systems, and Eureka Health demonstrate the potential for local startups to make a global impact.
For those ready to take the leap, remember that success comes by not only solving a problem but ensuring your audience understands why your solution matters. Invest in both your product and your marketing from day one, because the best ideas can only succeed if they’re heard.
Where will your idea fit on this list next year?
FAQ on Sacramento's Top Startups in 2025
1. Why is Sacramento gaining attention as a startup hub in 2025?
Sacramento's affordability compared to Silicon Valley, combined with government-backed grants and strong support from tech hubs like UC Davis and FastTrac, has created a fertile environment for startups. In 2025, the city allocated $450,000 in grants, leading to the creation of over 1,400 tech companies. Learn more about Sacramento's startup scene
2. Where can I submit a guest post about my startup?
If your startups need to drive targeted traffic and build authority with high-volume, niche-relevant content placements in articles that rank well not only in Google but also in Perplexity and ChatGPT, then you might want to publish your guest post in one of the F/MS Startup Game's blogs. Get a quality backlink
3. What is PowerSchool doing to revolutionize education technology?
PowerSchool, a leading EdTech company, continues to personalize learning through innovations like PowerBuddy AI solutions, which provide real-time insights for educators and students. Discover PowerSchool's innovations
4. How is Rhombus Systems enhancing security for businesses?
Rhombus Systems uses AI to deliver advanced security and surveillance solutions. They recently completed a Series C funding round in 2024 to scale operations and continue making security cost-effective. Explore Rhombus Systems
5. What challenges is Eureka Health addressing in healthcare?
Eureka Health leverages AI and machine learning to optimize clinical decisions, analyze patient data, and create personalized treatments, significantly impacting healthcare innovation. Learn more about Eureka Health
6. Is Sacramento a good location for biotech startups?
Yes, Sacramento is increasingly favorable for biotech companies like Digestiva, which secured Series A funding in 2024 to expand research in probiotics and gut health, reflecting the region’s focus on wellness and innovation. Check out Digestiva
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8. What makes One.bio a leader in clean energy solutions?
One.bio combines data-driven approaches with sustainability goals, making strides in reshaping global clean energy consumption and helping businesses meet environmental objectives. Learn about One.bio’s impact
9. How does Scooly innovate in flexible learning?
Scooly is redesigning how education works by embracing K-12 and higher-learning flexibility, offering personalized educational tools that recently secured pre-seed funding in March 2025. Explore Scooly
10. Why is Acorn Finance gaining momentum in the home improvement sector?
Acorn Finance simplifies home improvement financing by connecting consumers with lenders via its user-friendly platform, setting the standard in a niche market for financing solutions. Discover Acorn Finance
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
For the past several years Violetta has been living between the Netherlands and Malta, while also regularly traveling to different destinations around the globe, usually due to her entrepreneurial activities. This has led her to start writing about different locations and amenities from the POV of an entrepreneur. Here’s her recent article about best hotels in Italy to work from.
About the Publication
Fe/male Switch is an innovative startup platform designed to empower women entrepreneurs through an immersive, game-like experience. Founded in 2020 during the pandemic "without any funding and without any code," this non-profit initiative has evolved into a comprehensive educational tool for aspiring female entrepreneurs.The platform was co-founded by Violetta Shishkina-Bonenkamp, who serves as CEO and one of the lead authors of the Startup News branch. The Fe/male Switch team is located in several countries, including the Netherlands and Malta.
Mission and Purpose
Fe/male Switch Foundation was created to address the gender gap in the tech and entrepreneurship space. The platform aims to skill-up future female tech leaders and empower them to create resilient and innovative tech startups through what they call "gamepreneurship". By putting players in a virtual startup village where they must survive and thrive, the startup game allows women to test their entrepreneurial abilities without financial risk.
Key Features
The platform offers a unique blend of news, resources,learning, networking, and practical application within a supportive, female-focused environment:
- Skill Lab: Micro-modules covering essential startup skills
- Virtual Startup Building: Create or join startups and tackle real-world challenges
- AI Co-founder (PlayPal): Guides users through the startup process
- SANDBOX: A testing environment for idea validation before launch
- Wellness Integration: Virtual activities to balance work and self-care
- Marketplace: Buy or sell expert sessions and tutorials
Impact and Growth
Since its inception, Fe/male Switch has shown impressive growth:
- 3,000+ female entrepreneurs in the community
- 100+ startup tools built
- 5,000+ pieces of articles and news written
Partnerships
Fe/male Switch has formed strategic partnerships to enhance its offerings. In January 2022, it teamed up with global website builder Tilda to provide free access to website building tools and mentorship services for Fe/male Switch participants.
Recognition
Fe/male Switch has received media attention for its innovative approach to closing the gender gap in tech entrepreneurship. The platform has been featured in various publications highlighting its unique "play to learn and earn" model.
