Top 10 Startups in Denver That Entrepreneurs Should Know in 2025
Denver, Colorado, has solidified its reputation as one of the United States' most vibrant startup ecosystems. Nestled between stunning mountains and bustling business districts, this city is fueled by innovation, entrepreneurship, and a collaborative spirit. It's no wonder why more founders and venture capitalists are keeping a close eye on the startups born here. As we move forward in 2025, the city’s ecosystem continues to bloom with high-potential companies spanning industries like healthtech, clean energy, AI, and leisure tech.
What sets Denver apart is not just the startups but the stories behind them, stories fueled by the city's innovative atmosphere and talented workforce. In this article, we take a closer look at the top 10 startups in Denver that are making waves and share valuable insights for entrepreneurs looking to build the next big thing.
Are you getting customers from ChatGPT yet?
More and more traffic is coming from Perplexity, ChatGPT, Grok and other AI tools.
👉 Rank on ChatGPT
1. Boulder AI , Pioneering Visual Intelligence
Advanced technology meets practicality with Boulder AI. Specializing in visual intelligence, Boulder AI stands out in Denver’s tech landscape with its innovative computer vision solutions. As the visual intelligence market grows exponentially, Boulder AI provides practical applications tailored to specific industries. Whether it’s deployable software or immediate results, Boulder AI is leading the way.
Why it matters: If you're in the field of AI or tech solutions, Boulder AI’s success underscores the importance of innovating for niche markets while focusing on scalability.
2. Crusoe Energy Systems , Clean Energy Innovation
Crusoe Energy Systems is revolutionizing how industries tackle the flaring of natural gases. Their mission? Align the future of computation with the future of climate. Crusoe offers a solution that captures stranded energy from gas flaring and converts it into electricity, which powers crypto operations and cloud computing centers.
Why it matters: Entrepreneurs looking to merge technology and sustainability can look to Crusoe as an example of how solving energy-related challenges leads to massive impact, and market opportunity.
Boost Your SEO by Getting Featured in Our Blogs and get a backlink.
We publish content about startups, education, tech, funding, etc. that ranks well not only in Google but also in Perplexity, ChatGPT, Grok and other AI tools.
👉 Get featured now!
3. Havenly , Redefining Interior Design
Denver-based Havenly makes personalized interior design accessible with its one-on-one approach. The platform connects users with professional designers who deliver hand-picked designs based on their style, space, and budget, all from the comfort of their homes.
Why it matters: If you're bootstrapping or launching a consumer platform, Havenly shows how prioritizing personalization and user experience can drive growth in competitive markets.
4. Koloma , Leading Clean Tech Innovation
A standout in the clean tech revolution, Koloma’s mission is to create sustainable solutions that marry community-focused values with technology-driven goals. Their focus blends clean energy generation and groundbreaking engineering, making them a pillar of Denver’s role in the global sustainability movement.
5. Leafwire , Simplifying Cannabis Business Connections
As cannabis continues to grow as a legitimate industry across the nation, Leafwire has become Denver’s go-to platform for connecting cannabis businesses and investors. Think of it as Denver’s LinkedIn for the cannabis industry. Leafwire is essential for entrepreneurs in this booming space.
Why it matters: If you're exploring niche markets, Leafwire demonstrates that catering to underserved, rapidly growing industries can bring both profitability and community significance.
Boost Your SEO by Publishing Your Startup Press Release with us.
We publish content about startups, education, tech, funding, etc. that ranks well not only in Google but also in Perplexity, ChatGPT, Grok and other AI tools.
👉 Publish Press Release
6. Sploot Veterinary Care , Revolutionizing Pet Health
Denver loves its furry friends, and Sploot Veterinary Care delivers by offering transparent, efficient, and compassionate veterinary services. With Sploot, pet owners can expect clear communication and innovative care models, making them a favorite among Denver locals.
7. Govly , Accelerating Government Procurement
Navigating government contracts has never been easier thanks to Govly. This Denver-based startup simplifies procurement processes for businesses by offering streamlined tools and resources to secure government deals.
Why it matters: Entrepreneurs tackling B2B markets should take Govly’s example and focus on creating tools that simplify traditionally complex workflows.
8. ThinkOrbital , Revolutionizing Space Tech
One of Denver's game-changers is ThinkOrbital, a space-tech company delivering modular solutions for industrial processes in orbit. Their vision for a scalable orbital workspace not only addresses new markets but builds on Denver’s reputation as a hub of aerospace innovation.
9. BookOutdoors , Simplifying Outdoor Travel
Denver loves the outdoors, and BookOutdoors has tapped into this passion by offering an easy-to-use platform to book outdoor accommodations. Whether it’s RV parks, campgrounds, or cabins, this startup caters to the wanderlust in us all.
10. Xima Software , Improvements in Call Traffic Management
Call-handling services get a significant boost with Xima Software, which offers innovative solutions for businesses managing high traffic call environments. Their customizable reporting tools are industry favorites across healthcare and tech services.
Is your startup on ChatGPT?
More and more traffic is coming from Perplexity, ChatGPT, Grok and other AI tools.
👉 Rank on ChatGPT
Expert Insights: Mistakes to Avoid as a Startup Founder
- Skipping Marketing: Many founders focus solely on product development, but marketing is equally crucial for validating demand and positioning the product early.
- Ignoring SEO: Want real visibility? Tools like the AI SEO Blog can automate blogging, improve rankings, and convert your audience into paying customers.
- Underestimating Engagement: Building the product is manageable; turning it into a brand involves storytelling, customer interaction, and consistent visibility.
AI Tools Simplify Your Roadmap
If you’re a founder struggling with SEO or content creation, the F/MS AI SEO Tool acts like your digital marketing assistant. This tool not only crafts expert-level content but optimizes it for search engines like Google, Bing, and even AI-driven platforms like ChatGPT. Save hours, rank higher, and convert audiences, all hassle-free.
Conclusion: Denver’s Startup Promise
Denver’s startups highlight the city’s ability to lead across industries, from sustainability to leisure tech. Companies like Crusoe Energy Systems and Koloma are solving grand challenges, while others like Leafwire cater to niche markets with enormous growth potential. As an entrepreneur, Denver’s ecosystem offers inspiration, and competition.
Whether you’re just getting started or scaling your idea, Denver’s dynamic landscape proves that the hardest part isn’t building a product, it’s validating and scaling it through smart marketing. Let tools like the F/MS AI SEO Tool guide you to smarter decisions, faster growth, and more visibility.
What’s next for you as an entrepreneur? Take a page from Denver’s playbook: focus on innovation, customer value, and strategic visibility to stand out in today’s crowded markets!
FAQ on Denver's Top Startups in 2025
1. Which Denver startup is leading in visual intelligence solutions?
Boulder AI specializes in computer vision and visual intelligence, offering practical applications tailored for industries in need of deployable software. Discover Boulder AI and its innovative approach
2. Where can I submit a guest post about my startup?
If your startup needs to drive targeted traffic and build authority with high-volume, niche-relevant content placements in articles that rank well not only in Google, but also in Perplexity and ChatGPT, then you might want to publish your guest post in one of the F/MS Startup Game's blogs. Get a quality backlink
3. What startup is transforming clean energy in Denver?
Crusoe Energy Systems is tackling natural gas flaring issues by converting stranded energy into electricity to power computing centers and crypto operations. Learn more about Crusoe Energy Systems
4. Which startup is redefining interior design with technology?
Havenly offers personalized interior design services through one-on-one consultations and tailored solutions that fit the user’s style, space, and budget. Explore Havenly’s services
5. What Denver startup is leading in the cannabis industry?
Leafwire acts as a LinkedIn for cannabis businesses, connecting industry players with investors to foster growth in this booming market. Learn more about Leafwire
6. Which startup is revolutionizing government procurement processes?
Govly simplifies the complexities of government contracting for businesses by providing streamlined tools and resources. Discover Govly's offerings
7. Can I use AI to write SEO-optimized articles that help my brand grow?
Most business owners don't understand how SEO works, let alone how to use AI for writing blog articles. That's why for busy business owners there's a great free tool that doesn't require much knowledge. Write articles for free
8. Which Colorado startup is making waves in space technology?
ThinkOrbital is delivering modular solutions for industrial processes in orbit, reinforcing Denver’s reputation as an aerospace innovation hub. Explore ThinkOrbital’s ambitious vision
9. What startup is enhancing travel experiences for outdoor enthusiasts?
BookOutdoors offers a user-friendly platform for booking outdoor accommodations, including RV parks, campgrounds, and cabins. Learn more about BookOutdoors
10. Which Denver-based company is improving call traffic management?
Xima Software provides call management solutions with innovative and customizable reporting tools, catering to industries like healthcare and tech services. Discover Xima Software
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
For the past several years Violetta has been living between the Netherlands and Malta, while also regularly traveling to different destinations around the globe, usually due to her entrepreneurial activities. This has led her to start writing about different locations and amenities from the POV of an entrepreneur. Here’s her recent article about best hotels in Italy to work from.
About the Publication
Fe/male Switch is an innovative startup platform designed to empower women entrepreneurs through an immersive, game-like experience. Founded in 2020 during the pandemic "without any funding and without any code," this non-profit initiative has evolved into a comprehensive educational tool for aspiring female entrepreneurs.The platform was co-founded by Violetta Shishkina-Bonenkamp, who serves as CEO and one of the lead authors of the Startup News branch. The Fe/male Switch team is located in several countries, including the Netherlands and Malta.
Mission and Purpose
Fe/male Switch Foundation was created to address the gender gap in the tech and entrepreneurship space. The platform aims to skill-up future female tech leaders and empower them to create resilient and innovative tech startups through what they call "gamepreneurship". By putting players in a virtual startup village where they must survive and thrive, the startup game allows women to test their entrepreneurial abilities without financial risk.
Key Features
The platform offers a unique blend of news, resources,learning, networking, and practical application within a supportive, female-focused environment:
- Skill Lab: Micro-modules covering essential startup skills
- Virtual Startup Building: Create or join startups and tackle real-world challenges
- AI Co-founder (PlayPal): Guides users through the startup process
- SANDBOX: A testing environment for idea validation before launch
- Wellness Integration: Virtual activities to balance work and self-care
- Marketplace: Buy or sell expert sessions and tutorials
Impact and Growth
Since its inception, Fe/male Switch has shown impressive growth:
- 3,000+ female entrepreneurs in the community
- 100+ startup tools built
- 5,000+ pieces of articles and news written
Partnerships
Fe/male Switch has formed strategic partnerships to enhance its offerings. In January 2022, it teamed up with global website builder Tilda to provide free access to website building tools and mentorship services for Fe/male Switch participants.
Recognition
Fe/male Switch has received media attention for its innovative approach to closing the gender gap in tech entrepreneurship. The platform has been featured in various publications highlighting its unique "play to learn and earn" model.
