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Top 10 VCs for AI Startups in North America (2025)
2025-04-24 08:25 Top 10

Top 10 VCs for AI Startups in North America (2025)

Top 10 VCs for AI Startups in North America (2025)

The AI landscape is expanding rapidly, and investors are keen to tap into this dynamic sector. In 2025, various venture capitalists (VCs) have emerged as champions for artificial intelligence startups in North America. Here is a detailed overview of the Top 10 VCs for AI Startups in North America for 2025.
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1. Sequoia Capital

Focus: Broad tech, significant AI investments
Investment Stage: Seed to late-stage
AI Portfolio: Companies like Scale AI, Cohere, and many others.
Data Points:
  • Assets Under Management (AUM): Approximately $85 billion
  • AI Investment Track Record: Long history of backing AI leaders and unicorns
  • Geographic Focus: Global with strong presence in North America
  • Network: Extensive network and resources
  • Recent AI Deals: Active in generative AI and machine learning.
  • Learn more about Sequoia Capital

2. Andreessen Horowitz (a16z)

Focus: Technology with a strong emphasis on AI, software, and crypto.
Investment Stage: Seed to late-stage
AI Portfolio: Includes companies like Adept AI, Character AI, and others in various AI sub-sectors
Data Points:
  • AUM: Over $35 billion
  • AI Investment Track Record: Aggressive investments in both foundational AI and applied AI startups
  • Geographic Focus: Primarily North America
  • Value Add: Known for extensive content, network, and operational support
  • Recent AI Deals: Heavy focus on generative AI and AI infrastructure.
  • Discover Andreessen Horowitz
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3. Kleiner Perkins

Focus: Early-stage technology, with growing AI emphasis.
Investment Stage: Primarily seed and Series A
AI Portfolio: Investments in companies like Builders.ai, and others focused on AI applications.
Data Points:
  • AUM: Estimated to be around $10 billion
  • AI Investment Track Record: Has backed foundational tech companies, now focusing more on AI.
  • Geographic Focus: North America
  • Value Add: Offers mentorship, strategy, and recruiting support
  • Recent AI Deals: Moving into early-stage AI companies
  • Learn more about Kleiner Perkins

4. Lightspeed Venture Partners

Focus: Multi-stage tech with increasing attention to AI and machine learning.
Investment Stage: Seed to growth
AI Portfolio: Includes companies like Runway and others in different AI spaces.
Data Points:
  • AUM: Over $19 billion
  • AI Investment Track Record: Strong AI portfolio across various stages.
  • Geographic Focus: Global with a significant North American presence
  • Operational Support: Offers support in talent, marketing, and strategy
  • Recent AI Deals: Active in sectors like AI-driven automation and healthcare.
  • Explore Lightspeed Venture Partners

5. Accel

Focus: Multi-stage tech investments, with focus on AI and software
Investment Stage: Seed to growth
AI Portfolio: Investments include companies like UiPath and others with AI-enabled products
Data Points:
  • AUM: Approximately $20 billion
  • AI Investment Track Record: Long history of backing tech leaders including those leveraging AI
  • Geographic Focus: Global with strong focus on North America and Europe
  • Value Add: Extensive global network, helps with scaling
  • Recent AI Deals: Active in AI-driven SaaS and infrastructure
  • Learn more about Accel
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6. Khosla Ventures

Focus: Early-stage, high-risk tech, with a strong interest in deep AI.
Investment Stage: Seed and Series A
AI Portfolio: Focus on deep tech AI startups, including companies such as Vicarious
Data Points:
  • AUM: Estimated to be over $10 billion
  • AI Investment Track Record: Early adopter of AI technologies
  • Geographic Focus: Primarily North America
  • Value Add: Known for high-conviction investments and thought leadership
  • Recent AI Deals: Focus on AI in areas like robotics and biotech
  • Learn more about Khosla Ventures

7. Insight Partners

Focus: Growth-stage software companies, with a strong AI component
Investment Stage: Growth equity
AI Portfolio: Focus on AI-driven enterprise solutions, and companies such as Tractable
Data Points:
  • AUM: Over $90 billion
  • AI Investment Track Record: Extensive portfolio of growth-stage tech companies leveraging AI
  • Geographic Focus: Global with significant operations in North America
  • Operational Support: Offers deep operational expertise and support
  • Recent AI Deals: Focus on AI driven SaaS and enterprise software
  • Discover Insight Partners

8. Index Ventures

Focus: Multi-stage tech investments with an emphasis on AI and software
Investment Stage: Seed to growth
AI Portfolio: Investments include companies like Hugging Face and other leading AI startups
Data Points:
  • AUM: Estimated to be above $10 billion
  • AI Investment Track Record: Has a track record for spotting major tech trends early on
  • Geographic Focus: Global, with a strong presence in North America and Europe
  • Value Add: Network, operational expertise and global scaling
  • Recent AI Deals: Focused on AI infrastructure and applications
  • Learn more about Index Ventures

9. Tiger Global Management

Focus: Multi-stage technology investments, with a focus on AI driven companies
Investment Stage: Growth and late stage
AI Portfolio: Investments in companies like OpenAI and other AI focused companies.
Data Points:
  • AUM: Over $60 billion
  • AI Investment Track Record: Active in the AI space in recent years with large investments
  • Geographic Focus: Global, with focus on North America and Asia.
  • Value Add: Known for rapid growth funding
  • Recent AI Deals: Focus on generative AI and applied AI solutions.
  • Explore Tiger Global Management

10. Coatue

Focus: Multi-stage tech investments, including a strong focus on AI
Investment Stage: Growth and late-stage
AI Portfolio: Investments in companies like Anthropic and other large AI applications.
Data Points:
  • AUM: Over $70 billion
  • AI Investment Track Record: Invested in many prominent AI companies
  • Geographic Focus: Global, with a strong North American presence
  • Value Add: Network and late stage funding
  • Recent AI Deals: Focus on the leading edge of AI
  • Learn more about Coatue
Disclaimer: This list is based on available information as of January 15, 2025, and the venture capital landscape is subject to change. The "AI Portfolio" examples are not exhaustive and represent a small sample of their overall investments.
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FAQ

Q: Which VC has the largest assets under management in the AI sector?
A: Sequoia Capital leads with approximately $85 billion in assets under management. Learn more about Sequoia Capital.
Q: What stage of investments does Andreessen Horowitz focus on?
A: Andreessen Horowitz (a16z) invests from seed to late-stage startups, emphasizing technology, including AI. Discover Andreessen Horowitz.
Q: Which VC is known for backing early-stage, high-risk tech in AI?
A: Khosla Ventures specializes in early-stage investments, focusing on deep AI technologies. Learn more about Khosla Ventures.
Q: What value does Lightspeed Venture Partners provide to startups?
A: Lightspeed Venture Partners offers operational support in talent, marketing, and strategic growth. Explore Lightspeed Venture Partners.
Q: Which VC has a significant focus on AI-driven enterprise solutions?
A: Insight Partners concentrates on growth-stage investments, particularly in AI-driven enterprises. Visit Insight Partners.
Q: How does Kleiner Perkins support its AI portfolio companies?
A: Kleiner Perkins offers mentorship and strategic recruiting support to its portfolio companies. Learn more about Kleiner Perkins.
Q: What type of companies does Accel invest in?
A: Accel invests in multi-stage tech companies, focusing on those with AI capabilities, particularly in SaaS and infrastructure. Discover Accel.
Q: Which VC has shown recent activity in sectors like AI-driven healthcare?
A: Lightspeed Venture Partners has been active in investing in AI-driven automation and healthcare startups. Explore Lightspeed Venture Partners.
Q: What is a notable investment of Tiger Global Management in the AI space?
A: Tiger Global Management has invested in notable AI companies including OpenAI in recent years. Learn more about Tiger Global Management.
Q: What strategy does Coatue implement for its investments?
A: Coatue engages in multi-stage tech investments, with a strong focus on providing late-stage funding to leading AI applications. Discover Coatue.

About the Author

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.