Top 10 Accelerators for Deeptech Startups in North America 2025: A Comprehensive Guide
The deep tech startup ecosystem is evolving rapidly, and North America is home to some of the best accelerators that are fostering innovation across various sectors. These accelerators provide essential support ranging from funding to mentorship, ultimately helping founders scale their ventures. Here’s an in-depth look at the Top 10 Accelerators for Deeptech Startups in North America for 2025, complete with details on location, investment amounts, program duration, and links to their official websites.
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1. Y Combinator (YC)
Location: Mountain View, California, USA
Focus: Not exclusively deep tech, but has funded numerous successful deep tech companies.
Investment: $500,000 ($125,000 for 7% equity + $375,000 uncapped SAFE)
Program Duration: 3 months
Benefits: Access to an extensive alumni network, mentorship from industry leaders, and exposure during Demo Day.
Data Points: High funding rate, rigorous selection process, and recognized track record of producing successful startups.
2. Techstars
Location: Global (multiple locations in North America: Boston, New York, San Francisco)
Focus: Various industries including health tech, fintech, and clean tech.
Investment: $120,000 for 6% equity
Program Duration: 3 months
Benefits: Hands-on mentorship, access to a vast global investor network, and perks worth over $4 million.
Data Points: Known for its significant corporate partnerships and high success rate of funding rounds post-accelerator.
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3. 500 Global
Location: Palo Alto, California, USA
Focus: Early-stage startups with a global reach, including deep tech.
Investment: $150,000 (minus the $37,500 program fee) for 6% equity
Program Duration: 4 months
Benefits: Comprehensive founder-focused curriculum, mentorship, and access to a global network of successful entrepreneurs.
Data Points: Strong emphasis on community-driven growth, diverse program structure, and commitment to supporting founders structurally.
4. Plug and Play Tech Center
Location: Sunnyvale, California
Focus: Innovations across 40+ sectors including fintech and health.
Investment: Varies (no equity requirement for some programs)
Program Duration: 12 weeks
Benefits: Extensive corporate partnerships, mentorship, and access to a global innovation network.
Data Points: Notable for its industry-specific accelerator tracks and collaborative events with large corporations.
5. SOSV
Location: Multiple locations, including San Francisco and New York.
Focus: Deep tech and frontier technologies such as hardware, biotech, and software.
Investment: Varies by program
Program Duration: Varies
Benefits: In-depth mentorship, access to strong global networks, and potential follow-on funding support.
Data Points: Known for its deep tech focus, multiple vertical support, and extensive founder resources.
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6. AngelPad
Location: San Francisco, California
Focus: Early-stage startups across various industries with a tech emphasis.
Investment: $120,000 for 7% equity
Program Duration: 10 weeks
Benefits: Intense mentorship and an unmatched network of investors provide a supportive environment crafted for startups.
Data Points: Highly selective, providing extensive resources for product development and investor access.
7. MassChallenge
Location: Global (includes Boston, Switzerland, Israel)
Focus: Broad applications but notable for deep tech and science-based startups.
Investment: No equity taken, with grants and prizes made available.
Program Duration: Varies
Benefits: Access to a vast network of mentors and resources along with opportunities for non-dilutive funding.
Data Points: Emphasis on impact-driven innovations and a significant community engagement model.
8. Revtech Labs (Healthtech)
Location: Charlotte, North Carolina, USA
Focus: Health tech startups, especially post-launch and revenue-generating.
Investment: $40,000 along with potential follow-on funding opportunities.
Program Duration: 12 weeks
Benefits: Specialized mentoring and resources related to healthcare and medicine, along with investor connections.
Data Points: Focused exclusively on health tech, providing tailored resources for regional startups.
9. Accelerator Life Science Partners
Location: Seattle, WA
Focus: Early-stage ventures in Life Sciences and Biotechnology.
Investment: Varies
Program Details: Offers access to world-class laboratories, scientific expertise, and product launch support.
Benefits: Attention to life sciences startups with strong management support and financial investment possibilities.
Data Points: Highly specialized with a strong focus on regional industries and research facilities.
10. Polsky Deep Tech Ventures (University of Chicago)
Location: Chicago, IL
Focus: Transforming university innovations into startups with an emphasis on quantum technologies.
Investment: Varies
Program Details: Comprehensive support focused on the commercialization of deep tech research advancements.
Benefits: Direct access to university research facilities and expert guidance on commercialization methodologies.
Data Points: Strong university partnership with programs like Duality specifically targeted at quantum startups.
These accelerators represent a blend of well-established institutions and specialized programs geared towards nurturing deep tech innovation. Each offers unique resources and networks that can significantly impact the success trajectory of participating startups.
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FAQ
Q: What is Y Combinator known for?
A: Y Combinator (YC) is renowned for its accelerator program that has a strong emphasis on tech startups, including many in the deep tech sector. It offers substantial funding and access to a powerful alumni network. Learn more about Y Combinator.
Q: How much funding does Techstars provide to startups?
A: Techstars provides $120,000 for 6% equity, alongside hands-on mentorship and access to a global network of investors. Discover Techstars.
Q: What is the focus of 500 Global?
A: 500 Global focuses on early-stage startups with global ambitions, including those in the deep tech sector, providing $150,000 for 6% equity. Learn more about 500 Global.
Q: What makes Plug and Play Tech Center unique?
A: Plug and Play Tech Center offers industry-specific innovation across 40+ sectors, providing a variety of programs and partnerships with corporations, frequently with no equity requirement. Explore Plug and Play.
Q: What kind of startups does SOSV support?
A: SOSV supports startups focusing on deep tech and frontier technologies, offering a diverse set of verticals and a strong global presence. Learn more about SOSV.
Q: How selective is AngelPad as an accelerator?
A: AngelPad is highly selective, focusing on early-stage tech startups and providing $120,000 for 7% equity with intensive mentorship. Check out AngelPad.
Q: What is the investment model of MassChallenge?
A: MassChallenge does not take equity and instead provides grants and prizes to startups across various industries, with a significant focus on deep tech and impact-driven companies. Discover MassChallenge.
Q: What stage of startups does Revtech Labs specialize in?
A: Revtech Labs specializes in health tech startups that are post-launch and post-revenue, providing $40,000 and potential follow-on funding. Learn more about Revtech Labs.
Q: What kind of support does Accelerator Life Science Partners offer?
A: Accelerator Life Science Partners provides access to world-class laboratories and scientific expertise, focusing specifically on life sciences and biotechnology startups.
Q: What is the focus of Polsky Deep Tech Ventures?
A: Polsky Deep Tech Ventures is focused on translating university innovations into startups, emphasizing commercialization of research, particularly in quantum technologies. Check out Polsky Center.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
