Top 15 VCs for Deep Tech Startups in North America 2025
As the deep tech landscape continues to evolve, so do the venture capital firms that support innovative startups within this domain. In 2025, the following venture capitalists are considered the most influential players in funding deep tech startups in North America. Below is a comprehensive guide to the Top 15 VCs for Deep Tech Startups, detailing their investment focus, typical investment sizes, portfolio examples, and key data points.
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1. Andreessen Horowitz (a16z)
Investment Focus: AI, biotech, software, and other disruptive technologies.
Typical Investment Size: Varies widely, from seed to growth stages with substantial funding capacity.
Portfolio Examples: OpenAI, Oculus, SpaceX, Waymo.
Key Data Points: A large fund with a diverse portfolio and a history of backing highly successful deep tech companies. AUM $35B+.
2. Sequoia Capital
Investment Focus: AI, biotechnology, clean energy, and various other deep tech sectors.
Typical Investment Size: Ranges from early to late-stage investments, known for large growth rounds.
Portfolio Examples: OpenAI, Stripe, Nvidia, and many other tech giants.
Key Data Points: One of the most established and reputable VC firms with a strong track record in tech.
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3. Lux Capital
Investment Focus: Data science, chemistry, neuroscience, economics, electrical engineering, machine learning, and other deep tech areas.
Typical Investment Size: $100,000 to $100 million (early-stage).
Portfolio Examples: Airmap, Aeva, Eikon Therapeutics, and Light Form.
Key Data Points: AUM is over $5 Billion with a focus on cutting-edge science and tech.
4. Khosla Ventures
Investment Focus: Cleantech, health, and enterprise tech, emphasizing technology and science-based innovations.
Typical Investment Size: Varies, known for funding early to growth-stage companies.
Portfolio Examples: SunPower, C2FO, Helion Energy, 23andMe, Oscar.
Key Data Points: Established firm with a focus on impact investing and technological breakthroughs.
5. SOSV
Investment Focus: Deep tech, planetary health, and human health startups.
Typical Investment Size: Early-stage, with a focus on pre-seed and seed funding.
Portfolio Examples: Numerous startups in hardware, biotech, and sustainable solutions, including 8 unicorns, 58 IPOs, and 200+ early-stage deep tech companies.
Key Data Points: Global VC firm with a significant focus on early-stage, high-impact deep tech ventures.
6. Two Sigma Ventures
Investment Focus: AI, data science, healthcare, biotech, and fintech.
Typical Investment Size: $500,000 to $5 million (early-stage).
Portfolio Examples: Recursion Pharmaceuticals, GitLab, and Ripple.
Key Data Points: Leverages expertise in data and technology from its parent company, Two Sigma.
7. Grit Ventures
Investment Focus: Industrial automation, sustainability, supply chain, and connectivity.
Typical Investment Size: $250,000 to $5 million (pre-seed and seed).
Portfolio Examples: Trustwise, Integral AI, and Renovate Robotics.
Key Data Points: Focuses on transforming older industries with automation, AI, and robotics.
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8. Alumni Ventures
Investment Focus: Deep tech startups with a focus on solving significant challenges.
Typical Investment Size: Early to growth-stage.
Portfolio Examples: Almanac Labs, Beekin, OLIO, and Quantum Machines.
Key Data Points: Makes 15-20 venture investments each month with follow-on funding for successful companies.
9. ff Venture Capital
Investment Focus: Seed and early-stage deep tech companies.
Typical Investment Size: Seed and Series A funding.
Portfolio Examples: Various startups across AI, robotics, and biotech.
Key Data Points: One of the best performing seed and early-stage VCs.
10. Ocean Azul Partners
Investment Focus: B2B software and deep tech with a focus on North America and companies targeting the U.S. market.
Typical Investment Size: $200K - $2M initially.
Portfolio Examples: Startups that have an MVP level product with paying or pilot customers.
Key Data Points: Actively engages in investments and holds board seats.
11. Lightspeed Venture Partners
Investment Focus: Multi-stage investments in enterprise technology, consumer, cleantech, and biotechnology.
Typical Investment Size: Wide range, from early to growth stages.
Portfolio Examples: Many successful tech companies across various sectors.
Key Data Points: Global investment approach with a hands-on approach to supporting entrepreneurs.
12. Atlantic Bridge Ventures
Investment Focus: Breakthrough technologies in the deep tech sector.
Typical Investment Size: Varies.
Portfolio Examples: Not specified in the source, but they focus on deep tech.
Key Data Points: Known for accelerating innovation and transformation in the deep tech sector.
13. Main Sequence Ventures
Investment Focus: Catalyzing breakthrough innovations in deep tech.
Typical Investment Size: Early to growth-stage.
Portfolio Examples: Not specified, but invests in deep tech.
Key Data Points: Significant contributions to the development and growth of deep tech startups.
14. Good Growth Capital
Investment Focus: Supporting innovative deep tech startups with potential for groundbreaking advancements.
Typical Investment Size: Early-stage.
Portfolio Examples: Not specified, but they focus on deep tech.
Key Data Points: Invests in startups with groundbreaking advancements in various industries.
15. Walden Catalyst
Investment Focus: Identifying and funding groundbreaking startups in deep tech.
Typical Investment Size: Early to growth-stage.
Portfolio Examples: Not specified but known for fueling innovation in deep tech.
Key Data Points: Focused on fueling disruption and innovation in the deep tech sector.
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FAQ
Q: What is the focus of Andreessen Horowitz (a16z)?
A: Andreessen Horowitz specializes in AI, biotech, software, and other disruptive technologies, with a diverse portfolio including successful firms like OpenAI and SpaceX. Learn more about Andreessen Horowitz.
Q: What investment size does Sequoia Capital typically handle?
A: Sequoia Capital usually invests in early to late-stage ventures, known for substantial funding in growth rounds, with notable investments in companies like Stripe and Nvidia. Discover Sequoia Capital.
Q: What is Lux Capital’s investment focus?
A: Lux Capital targets deep tech areas such as data science, chemistry, and machine learning, generally investing between $100,000 to $100 million in early-stage companies. Explore Lux Capital.
Q: How much does Khosla Ventures typically invest?
A: Khosla Ventures invests at various stages, with a focus on impactful technology and scientific innovations, funding well-known firms like 23andMe. Learn more about Khosla Ventures.
Q: What type of companies does SOSV focus on?
A: SOSV invests primarily in deep tech, planetary health, and human health startups, with a strong emphasis on early-stage funding for high-impact ventures. Discover SOSV.
Q: What kind of investments does Two Sigma Ventures make?
A: Two Sigma Ventures invests in AI, data science, healthcare, and fintech, typically ranging from $500,000 to $5 million, supporting promising startups like GitLab. Explore Two Sigma Ventures.
Q: What is Grit Ventures known for?
A: Grit Ventures focuses on industrial automation and sustainability, generally investing between $250,000 to $5 million in transformative technologies. Learn more about Grit Ventures.
Q: What is the approach of Alumni Ventures in funding?
A: Alumni Ventures invests in deep tech startups aimed at significant problem-solving, making around 15-20 venture investments monthly across early to growth stages. Discover Alumni Ventures.
Q: At what stage does ff Venture Capital typically invest?
A: ff Venture Capital focuses on seed and early-stage deep tech companies, primarily through Seed and Series A funding rounds. Explore ff Venture Capital.
Q: What distinguishes Ocean Azul Partners in the VC landscape?
A: Ocean Azul Partners targets B2B software and deep tech startups within North America, usually investing between $200K to $2M in companies with MVP-level products. Learn more about Ocean Azul Partners.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
