Top 10 VCs for Deep Tech Startups in North America 2025
The deep tech landscape is expanding rapidly as startups focus on transformative technologies. In 2025, venture capital firms specializing in deep tech are anticipated to play a crucial role in fostering innovation. The following is a curated list of the Top 10 VCs for Deep Tech Startups in North America, detailing their investment focus, history, and impressive portfolios.
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1. SOSV
Focus: Deep tech, planetary health, and human health, with multi-stage investment.
Location: Princeton, New Jersey
Assets Under Management (AUM): $1.5 Billion+
Investment Stage: Pre-seed through growth, with accelerator programs like HAX (hard tech) and IndieBio (life sciences).
Portfolio Highlights: NotCo, R-Zero Systems, OpenTrons; 8 unicorns in portfolio.
Activity: One of the most active deep tech investors globally, doing 300+ investments per year.
2. Andreessen Horowitz (a16z)
Focus: Broad tech focus, with significant investments in AI, robotics, and biotech.
Location: Silicon Valley, California
Funds Raised: $7.1 Billion over 7 funds.
Investment Stage: All stages, from seed to growth.
Portfolio Highlights: Airbnb, Instacart, People.ai, many other tech unicorns.
Expertise: Extensive team of engineers, executives, business leaders, and academics.
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3. Lux Capital
Focus: Deep tech startups in areas like data science, chemistry, neuroscience, and AI.
Location: New York and Menlo Park, California
AUM: $5 Billion +
Investment Range: $100,000 to $100 million.
Portfolio Highlights: Aeva, Auris, Desktop Metal, Recursion, SailDrone, Matterport.
Stage: Seed and Series A.
4. Data Collective (DCVC)
Focus: Seed, Series A, and growth-stage companies in climate, crypto, cybersecurity, aerospace, and AI/ML.
Location: Palo Alto and San Francisco, California
Funds Raised: $725 million
Investments: 469 investments, 135 exits.
Stage: Seed to Growth
Portfolio Highlights: Rigetti Computing, Q-CTRL.
5. Sequoia Capital
Focus: High-growth potential and market disruption across multiple sectors including robotics and AI.
Location: Menlo Park, California
Investment Stage: Seed to Growth
Portfolio Highlights: Apple, Google, Oracle, Zipline, Starship Technologies.
Track Record: Known for backing transformative companies and tech giants.
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6. Alumni Ventures Deep Tech Fund
Focus: Diversified investments in deep tech companies.
Location: Manchester, New Hampshire
Activity: Invests in 15 to 20 companies per month.
Portfolio: More than 1,000 portfolio companies.
Funds Raised: Over $1 billion.
Investment Stage: Seed to Late-stage.
7. M12 (Microsoft Ventures)
Focus: Artificial intelligence investments in North America and Israel.
Location: Global, with focus on North America and Israel
Investment Stage: Early-stage B2B companies.
Access: Provides portfolio companies with access to Microsoft's ecosystem, professionals, and resources.
Portfolio Highlight: TwentyBN, a company helping robots pick up human mannerisms.
8. General Catalyst
Focus: Early and growth-stage equity investments in tech companies.
Location: US Based
Investment Stage: Early and Growth Stage
Portfolio Highlights: Grammarly, Eightfold.ai, 6D.ai, Helsing, and Mistral.
Strategy: Invests in established businesspeople who have already made a name for themselves in the tech industry.
9. Norwest Venture Partners
Focus: Health Care, Enterprise (AI, SaaS, Cybersecurity), Consumer Internet.
Location: Palo Alto, California
Investment Stage: Early to Late-stage.
Funds Raised: $3 Billion in latest fund (16th fund)
Investments: 1270 investments, 297 exits.
Check Size: $20M to $200M
10. Khosla Ventures
Focus: Technology-focused, with a significant interest in deep tech areas such as advanced materials, AI, and biotechnology.
Location: Menlo Park, California
Investment Stage: Seed, Early Stage, and Growth Stage
Investment Style: Known for backing bold ideas and disruptive technologies.
Portfolio Highlights: A range of companies across different sectors, including clean tech and healthcare.
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FAQ
Q: What is SOSV's investment focus?
A: SOSV focuses on deep tech, planetary health, and human health with a multi-stage investment approach. Learn more about SOSV.
Q: How much capital has Andreessen Horowitz raised?
A: Andreessen Horowitz has raised $7.1 billion over 7 funds focusing on a broad tech spectrum including AI, robotics, and biotech. Discover more about Andreessen Horowitz.
Q: What types of startups does Lux Capital invest in?
A: Lux Capital targets deep tech startups in areas such as data science, chemistry, neuroscience, and AI, with an assets under management exceeding $5 billion. Find out more about Lux Capital.
Q: What is the specialization of Data Collective (DCVC)?
A: Data Collective specializes in seed, Series A, and growth-stage companies within fields like climate, crypto, cybersecurity, and AI/ML. Read more on DCVC’s website.
Q: What notable companies has Sequoia Capital invested in?
A: Sequoia Capital has an impressive track record, having backed companies like Apple, Google, and Oracle among others. Learn about Sequoia Capital.
Q: How frequently does Alumni Ventures Deep Tech Fund invest?
A: Alumni Ventures Deep Tech Fund invests in 15 to 20 companies per month, focusing on diversified deep tech investments. Explore more about Alumni Ventures.
Q: What is M12's investment strategy?
A: M12, Microsoft's venture capital arm, invests in early-stage B2B companies focusing on artificial intelligence. Check out M12.
Q: Which companies have General Catalyst invested in?
A: General Catalyst has invested in tech companies like Grammarly, Eightfold.ai, and 6D.ai targeting early and growth-stage investments. Learn more about General Catalyst.
Q: What is Norwest Venture Partners known for?
A: Norwest Venture Partners focuses on health care, enterprise, and consumer internet sectors, with a significant number of investments and exits. Find out about Norwest Venture Partners.
Q: What sectors does Khosla Ventures focus on?
A: Khosla Ventures has a technology-focused investment strategy with a strong interest in advanced materials, AI, and biotechnology. Discover Khosla Ventures.
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
