TOP 10 Startups in Santiago, Chile in 2025: Examples of Innovation to Inspire Entrepreneurs
Santiago, Chile, has firmly established itself as one of South America's most vibrant hubs for innovation and entrepreneurship. With its strong governmental support, burgeoning tech talent, and a focus on sustainability and innovation, the city has birthed a wave of startups that are globally recognized. From groundbreaking FoodTech initiatives to revolutionary healthtech platforms, Santiago is a hotspot for the entrepreneurial spirit.
Ready to uncover the Top 10 startups in Santiago for 2025? Keep reading to discover what makes these companies remarkable, tips to propel your own startup's growth, and how to amplify your visibility globally.
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Why Startups are Thriving in Santiago in 2025
Chile is ranked 39th globally as a startup ecosystem, with Santiago its beating heart. Nearly 91% of Chilean startups are based in the capital, and they benefit from a unique combination of high-speed internet (213.73 Mbps, the fastest in South America), solid investor interest, and immense government support through initiatives like Start-Up Chile.
Notable startups such as unicorns NotCo and Betterfly further highlight Santiago’s strengths in FoodTech, FinTech, and sustainability-driven ventures.
If you’re planning to launch a business here, start thinking about marketing early. It’s not about just building a great product; marketing it well is what will actually validate your idea. Tools like the F/MS AI Article Writing Tool ensure that your startup can gain traction online with SEO-optimized content and authoritative articles.
Top 10 Startups in Santiago, Chile in 2025
1. The Wild Foods
Industry: FoodTech
The Wild Foods has disrupted the natural foods market with its transparent, sustainable, and health-focused food products like sugar-free protein bars and nutrient-packed shakes. Its creativity isn't just limited to products; their marketing strategy has captured global interest. Now entering Series A with $25M in funding, The Wild Foods is showing FoodTech how to combine branding and nutrition seamlessly.
📌 Visit The Wild Foods Website
2. SPOT
Industry: AI Video Analytics
SPOT turns raw video footage into actionable insights through advanced analytics. Whether it’s security systems or operational efficiency, this tool identifies patterns that are crucial for decision-making. Its seed funding of $2M showcases SPOT's potential in reshaping how we interact with surveillance and operational data.
📌 Learn more about SPOT Video Analytics
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3. Keirón
Industry: HealthTech
Keirón is modernizing healthcare in Chile by focusing on the patient experience. Its omnichannel platform digitizes the patient journey, from diagnosis to recovery. With $1.7M in seed funding, Keirón is combining tech innovation with compassion in healthcare.
📌 Explore Keirón Salud's innovative solution
4. PhageLab
Industry: Agricultural Tech / Animal Welfare
PhageLab is taking a revolutionary approach to animal farming by employing bacteriophage technology to combat harmful bacteria in livestock. This innovation not only improves animal welfare but also boosts long-term productivity on farms. Backed by a Series A round of $11M, PhageLab represents a bold step in sustainable agriculture.
📌 Check out PhageLab's farming solutions
5. Toku
Industry: FinTech
Managing subscription payments across LATAM is no small feat, but Toku is doing just that. With $9.3M in Series A funding, its innovative payment solutions make them a standout in the FinTech space. Expect this startup to rapidly expand beyond Chile.
📌 See how Toku streamlines payment solutions
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6. Xepelin
Industry: B2B FinTech
Xepelin has a mission to simplify finance for businesses, providing them with tailored solutions for working capital and liquidity management. This startup is securing its position as a crucial player in the Latin American financial landscape.
📌 Dive deeper into Xepelin's impact on B2B finance
7. Global 66
Industry: Payments and Remittances
Global 66 is giving traditional remittance services a run for their money with its transparent, fast, and low-cost transactions. This FinTech startup has experienced exponential growth by solving a common pain point for millions.
📌 Learn more about Global 66's services
8. Fintual
Industry: Investment Tech
For individuals and companies looking to grow their savings, Fintual has emerged as a go-to platform. Its user-friendly interface and clear investment options make it a preferred choice for modern wealth management.
📌 Check out Fintual's innovative platform
9. Kredito
Industry: FinTech / Small Business Solutions
Kredito's year-over-year revenue has exploded by 300%, thanks to its tools designed specifically for small businesses. Not only has it simplified access to credit, but its NPS score of 78 also highlights unmatched customer loyalty.
📌 Discover Kredito's small business solutions
10. Buk
Industry: HR Tech
Buk is a powerhouse in Human Resources technologies, streamlining payroll, recruitment, and employee engagement for businesses across Chile and LATAM. Its commitment to design and customer satisfaction keeps it at the forefront of HR innovations.
📌 Learn about Buk's HR solutions
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Steps to Emulate Their Success
- Master Marketing First
- Building a working product is one thing, but marketing is the real challenge. Use tools like the F/MS AI SEO Blog to automate your content strategy and optimize your search engine rankings.
- Focus on Customer Pain Points
- Each of these startups succeeded because they tackled a real, defined problem. Validate your business idea by solving pain points that matter.
- Leverage Free Resources
- Platforms like F/MS Marketing Directories allow you to list your business in thousands of directories, giving you a headstart in building visibility.
Common Mistakes to Avoid
- Skipping Collaboration: Santiago's startup ecosystem thrives on partnerships. Networking is critical.
- Weak Digital Strategy: With businesses moving faster online, failing to adopt SEO-focused marketing strategies often leads to lackluster growth.
- Overlooking Scalability: Invest in tech infrastructure that can grow as your startup does.
Conclusion: Why These Startups Deserve the Spotlight
The startups thriving in Santiago today are not just innovators, they’re nation-builders who are cementing Chile’s place in the global startup landscape. Whether you're an aspiring entrepreneur or an investor, studying these success stories can provide profound lessons in resilience, market fit, and execution. Santiago is proof that with the right ecosystem, ideas turn into global movements.
Take the leap and enhance your visibility with tools like the F/MS AI Article Writing Tool, because the world can’t invest in, partner with, or amplify what it doesn’t know exists.
So, what's stopping you? Let Santiago’s top 10 startups of 2025 inspire your own path to greatness. Share this article, celebrate innovation, and keep dreaming big.
FAQ on the Top 10 Startups in Santiago, Chile in 2025
1. Why is Santiago a hub for startups in 2025?
Santiago has become a hotbed for entrepreneurial activity because of its strong government support through initiatives like Start-Up Chile, its fast internet speeds (the fastest in South America at 213.73 Mbps), and a diverse talent pool. The city is home to 91% of Chile’s startups. Learn more about Santiago's startup ecosystem
2. Where can I submit a guest post about my startup?
If your startup needs to drive targeted traffic and build authority with high-volume, niche-relevant content placements in articles that rank well not only in Google, but also in Perplexity and ChatGPT, then you might want to publish your guest post in one of the F/MS Startup Game's blogs. Get a quality backlink
3. Which startup is leading in FoodTech innovation?
The Wild Foods stands out in FoodTech with its sugar-free protein bars and nutrient-packed shakes. Its Series A funding of $25M highlights its traction. Explore The Wild Foods' innovative products
4. How are Chilean startups innovating in FinTech?
Startups like Toku and Xepelin have disrupted the LATAM financial sector with subscription payment systems and liquidity management solutions, respectively. Both are scaling rapidly, with Toku raising $9.3M in Series A funding. Discover Toku's payment solutions
5. Are there any health-focused tech startups in Santiago?
Yes, Keirón is modernizing healthcare with an omnichannel platform. It digitizes the patient journey, from diagnosis to recovery, and raised $1.7M in seed funding. Learn about Keirón's health tech solutions
6. Which Santiago startup focuses on sustainability in agriculture?
PhageLab is revolutionizing agriculture with its bacteriophage technology that combats harmful bacteria in livestock, promoting animal welfare and productivity on farms. Check out PhageLab's approach to sustainable farming
7. Can I use AI to write SEO-optimized articles that help my brand grow?
Most business owners don't understand how SEO works, let alone how to use AI for writing blog articles. That's why for busy business owners, there's a great free tool that doesn't require much knowledge. Write articles for free
8. What is the best startup for small business credit solutions in Santiago?
Kredito is a standout for Chilean small businesses, offering simplified credit access. Its 300% YoY revenue growth in 2025 highlights its success. Explore Kredito's credit solutions
9. Is there an HR Tech leader in Santiago?
Yes, Buk is streamlining HR processes like payroll, recruitment, and engagement across LATAM. It's known for its user-friendly design and customer satisfaction. Learn about Buk's HR solutions
10. How has Santiago positioned itself globally as a startup hub?
Santiago is now ranked 39th globally in the startup ecosystem, boasting globally recognized unicorns like NotCo and Betterfly. Its vibrant innovation culture and governmental backing make it a regional powerhouse. Discover Santiago's rise in the global startup landscape
About the Author
Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.
Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).
She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the "gamepreneurship" methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond and launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks.
For the past several years Violetta has been living between the Netherlands and Malta, while also regularly traveling to different destinations around the globe, usually due to her entrepreneurial activities. This has led her to start writing about different locations and amenities from the POV of an entrepreneur. Here’s her recent article about best hotels in Italy to work from.
About the Publication
Fe/male Switch is an innovative startup platform designed to empower women entrepreneurs through an immersive, game-like experience. Founded in 2020 during the pandemic "without any funding and without any code," this non-profit initiative has evolved into a comprehensive educational tool for aspiring female entrepreneurs.The platform was co-founded by Violetta Shishkina-Bonenkamp, who serves as CEO and one of the lead authors of the Startup News branch. The Fe/male Switch team is located in several countries, including the Netherlands and Malta.
Mission and Purpose
Fe/male Switch Foundation was created to address the gender gap in the tech and entrepreneurship space. The platform aims to skill-up future female tech leaders and empower them to create resilient and innovative tech startups through what they call "gamepreneurship". By putting players in a virtual startup village where they must survive and thrive, the startup game allows women to test their entrepreneurial abilities without financial risk.
Key Features
The platform offers a unique blend of news, resources,learning, networking, and practical application within a supportive, female-focused environment:
- Skill Lab: Micro-modules covering essential startup skills
- Virtual Startup Building: Create or join startups and tackle real-world challenges
- AI Co-founder (PlayPal): Guides users through the startup process
- SANDBOX: A testing environment for idea validation before launch
- Wellness Integration: Virtual activities to balance work and self-care
- Marketplace: Buy or sell expert sessions and tutorials
Impact and Growth
Since its inception, Fe/male Switch has shown impressive growth:
- 3,000+ female entrepreneurs in the community
- 100+ startup tools built
- 5,000+ pieces of articles and news written
Partnerships
Fe/male Switch has formed strategic partnerships to enhance its offerings. In January 2022, it teamed up with global website builder Tilda to provide free access to website building tools and mentorship services for Fe/male Switch participants.
Recognition
Fe/male Switch has received media attention for its innovative approach to closing the gender gap in tech entrepreneurship. The platform has been featured in various publications highlighting its unique "play to learn and earn" model.
